Detailed information of TA system TA285621

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1549843..1550422
• Replicon: chromosome
• Accession: NZ_LN831036
• Organism: Staphylococcus aureus strain NCTC13435

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: AT694_RS07565
• Protein ID: WP_001025401.1
• Coordinates: 1550177..1550422 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1549843..1550208 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AT694_RS07525	1546585..1547142	-	558	WP_000645042.1	DUF2815 family protein	-
AT694_RS07530	1547168..1548334	-	1167	WP_000762551.1	DUF2800 domain-containing protein	-
AT694_RS07535	1548331..1548693	-	363	WP_000279446.1	hypothetical protein	-
AT694_RS07540	1548708..1549031	-	324	WP_000175000.1	hypothetical protein	-
AT694_RS07545	1549111..1549272	-	162	WP_001285955.1	DUF1270 family protein	-
AT694_RS07550	1549285..1549548	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
AT694_RS07555	1549573..1549788	-	216	WP_001036301.1	hypothetical protein	-
AT694_RS07560	1549843..1550208	+	366	WP_001128433.1	hypothetical protein	Antitoxin
AT694_RS07565	1550177..1550422	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
AT694_RS07570	1550438..1550686	-	249	WP_000272861.1	helix-turn-helix domain-containing protein	-
AT694_RS07575	1550850..1551173	+	324	WP_001260486.1	helix-turn-helix domain-containing protein	-
AT694_RS07580	1551186..1551647	+	462	WP_000525006.1	hypothetical protein	-
AT694_RS07585	1551664..1552098	+	435	WP_001226136.1	hypothetical protein	-
AT694_RS07590	1552127..1552522	+	396	WP_000449655.1	hypothetical protein	-
AT694_RS07595	1552612..1552758	+	147	WP_001013104.1	hypothetical protein	-
AT694_RS07600	1552755..1553369	-	615	WP_000191459.1	hypothetical protein	-
AT694_RS14570	1553495..1554701	+	1207	Protein_1455	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukF-PV / lukS-PV	1506153..1572344	66191

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T285621 WP_001025401.1 NZ_LN831036:c1550422-1550177 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT285621 NZ_LN831036:1549843-1550208 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin