Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1297673..1298312 Replicon chromosome
Accession NZ_LN831035
Organism Haemophilus influenzae strain NCTC8143

Toxin (Protein)


Gene name higB Uniprot ID Q4QJX7
Locus tag AT683_RS06410 Protein ID WP_005650215.1
Coordinates 1297673..1297978 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AT683_RS06415 Protein ID WP_005650217.1
Coordinates 1297989..1298312 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT683_RS06390 1293103..1295142 - 2040 WP_038441065.1 excinuclease ABC subunit B -
AT683_RS06400 1295757..1296725 - 969 WP_038441067.1 zinc transporter permease subunit ZevB -
AT683_RS06405 1296728..1297348 - 621 WP_005694310.1 zinc transporter binding subunit ZevA -
AT683_RS06410 1297673..1297978 + 306 WP_005650215.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AT683_RS06415 1297989..1298312 + 324 WP_005650217.1 HigA family addiction module antidote protein Antitoxin
AT683_RS06420 1298475..1300145 + 1671 WP_005650218.1 energy-dependent translational throttle protein EttA -
AT683_RS06425 1300207..1300548 + 342 WP_005652996.1 SirB2 family protein -
AT683_RS06430 1300553..1302523 + 1971 WP_011961904.1 tRNA(Met) cytidine acetyltransferase TmcA -
AT683_RS09690 1302520..1302693 + 174 WP_011272700.1 DUF5363 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-99)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-82)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 12301.93 Da        Isoelectric Point: 9.0853

>T285618 WP_005650215.1 NZ_LN831035:1297673-1297978 [Haemophilus influenzae]
MFNLKREHFRDDYLYRFYQYGDTHSKIPSNLYKVLARKLDMISASENINDLRSPPANHLELLEPKENKIYSIRVNKQYRL
IFKYENNEVNNLYLDPHSYNL

Download         Length: 306 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12347.17 Da        Isoelectric Point: 6.8804

>AT285618 WP_005650217.1 NZ_LN831035:1297989-1298312 [Haemophilus influenzae]
MMTRKPTSVGEILQEEFLEPLSLKISDLAQILDVHRNTASNIVNNSSRITLEMAVKLAKVFDTTPEFWLNLQTRIDLWDL
EHNKRFQQSLANVKPALHRHDTSTFAM

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806EC70

Antitoxin

Source ID Structure

References