Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 674019..674688 Replicon chromosome
Accession NZ_LN831035
Organism Haemophilus influenzae strain NCTC8143

Toxin (Protein)


Gene name higB Uniprot ID A0A2R3G0F4
Locus tag AT683_RS03405 Protein ID WP_015701504.1
Coordinates 674019..674402 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A502K5Z3
Locus tag AT683_RS03410 Protein ID WP_005651224.1
Coordinates 674386..674688 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT683_RS03370 670776..671099 + 324 WP_015701510.1 DUF2190 family protein -
AT683_RS03375 671080..671391 + 312 WP_015701509.1 hypothetical protein -
AT683_RS03380 671394..671924 + 531 WP_015701508.1 phage tail protein -
AT683_RS03385 671933..672343 + 411 WP_038440699.1 phage tail protein -
AT683_RS03390 672346..672996 + 651 WP_050846007.1 hypothetical protein -
AT683_RS03395 673271..673678 + 408 WP_038440705.1 hypothetical protein -
AT683_RS03400 673723..673950 + 228 WP_058222178.1 DUF4035 domain-containing protein -
AT683_RS03405 674019..674402 + 384 WP_015701504.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AT683_RS03410 674386..674688 + 303 WP_005651224.1 XRE family transcriptional regulator Antitoxin
AT683_RS03415 674704..674940 + 237 WP_101494098.1 hypothetical protein -
AT683_RS03420 674992..678384 + 3393 WP_058222179.1 tape measure protein -
AT683_RS03425 678393..678725 + 333 WP_038440713.1 phage tail protein -
AT683_RS09670 678817..678975 + 159 WP_005651234.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 642192..692498 50306


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-81)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14868.05 Da        Isoelectric Point: 4.4987

>T285616 WP_015701504.1 NZ_LN831035:674019-674402 [Haemophilus influenzae]
MKQEWEVILQDPLLNWLETLAEDDVLKIYAALELLSTEGPQLSRPYADTLQGSKYTNLKELRVQSKLSVFRLFYIFDPVR
QAIVLCGGDKKGKKEKLFYKEMIALAEQTYDDYLSELTKEQENEREI

Download         Length: 384 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11258.21 Da        Isoelectric Point: 9.5655

>AT285616 WP_005651224.1 NZ_LN831035:674386-674688 [Haemophilus influenzae]
MSVKFKDLMNNLPAEKQAKVKAMADDMRMELQLYRIREELELSQKQMAEALSISQPSVVALEKRGNDIKLSSVKRYIEAM
GGVLNLSVELPTGKTVTFNL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R3G0F4

Antitoxin

Source ID Structure
AlphaFold DB A0A502K5Z3

References