Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5280517..5281112 Replicon chromosome
Accession NZ_LN831024
Organism Pseudomonas aeruginosa strain NCTC10332

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag AT700_RS29905 Protein ID WP_003113526.1
Coordinates 5280834..5281112 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AT700_RS24300 Protein ID WP_003099268.1
Coordinates 5280517..5280822 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT700_RS24265 5275658..5276506 + 849 WP_003117426.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
AT700_RS24275 5276673..5277614 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
AT700_RS24280 5277731..5278345 + 615 WP_003095013.1 50S ribosomal protein L25/general stress protein Ctc -
AT700_RS24285 5278387..5278971 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
AT700_RS24290 5279012..5280112 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
AT700_RS24300 5280517..5280822 - 306 WP_003099268.1 HigA family addiction module antidote protein Antitoxin
AT700_RS29905 5280834..5281112 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AT700_RS24305 5281441..5283669 + 2229 WP_003099265.1 TonB-dependent receptor -
AT700_RS24310 5283739..5284386 - 648 WP_003095021.1 carbonate dehydratase -
AT700_RS24315 5284448..5285686 - 1239 WP_009316205.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T285602 WP_003113526.1 NZ_LN831024:c5281112-5280834 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT285602 WP_003099268.1 NZ_LN831024:c5280822-5280517 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References