Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4622516..4623197 Replicon chromosome
Accession NZ_LN831024
Organism Pseudomonas aeruginosa strain NCTC10332

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AT700_RS21240 Protein ID WP_015503432.1
Coordinates 4622832..4623197 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A643IYQ7
Locus tag AT700_RS21235 Protein ID WP_034071998.1
Coordinates 4622516..4622839 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT700_RS21210 4618429..4619067 + 639 WP_003119439.1 hypothetical protein -
AT700_RS21215 4619310..4619645 + 336 WP_003140884.1 TM2 domain-containing protein -
AT700_RS21220 4619819..4620337 + 519 WP_012614469.1 PAAR domain-containing protein -
AT700_RS21225 4620334..4621035 + 702 WP_048521411.1 VRR-NUC domain-containing protein -
AT700_RS21230 4621052..4622140 + 1089 WP_048521414.1 DUF3396 domain-containing protein -
AT700_RS21235 4622516..4622839 - 324 WP_034071998.1 XRE family transcriptional regulator Antitoxin
AT700_RS21240 4622832..4623197 - 366 WP_015503432.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AT700_RS21245 4623461..4623700 - 240 WP_048521765.1 hypothetical protein -
AT700_RS21250 4623907..4624179 + 273 WP_003085667.1 hypothetical protein -
AT700_RS21255 4624198..4624623 - 426 WP_017002478.1 VOC family protein -
AT700_RS21260 4624724..4625608 + 885 WP_003085663.1 LysR family transcriptional regulator -
AT700_RS21265 4625581..4626534 - 954 WP_003085661.1 LysR family transcriptional regulator -
AT700_RS21270 4626755..4627189 + 435 WP_003116494.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-86)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13798.14 Da        Isoelectric Point: 4.8219

>T285601 WP_015503432.1 NZ_LN831024:c4623197-4622832 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHPHSSGINGSRPGHMRELRTQHGGRPFRTLYAFDPRRSA
ILPIGGDKTGDDRWYELNVPIADRLHDEHLHQLREEGLIDG

Download         Length: 366 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11926.76 Da        Isoelectric Point: 6.4751

>AT285601 WP_034071998.1 NZ_LN831024:c4622839-4622516 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEAQARVEAKAQELLAEMPLNELRQARGLSQKMLSEVLQVQQPAIAKMERRTDMYISTLRSHIEAMG
GHLEVIARFPDGAVKISNFADIEETGA

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A643IYQ7

References