Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4406779..4407506 Replicon chromosome
Accession NZ_LN681227
Organism Xenorhabdus nematophila AN6/1

Toxin (Protein)


Gene name higB Uniprot ID D3VFW9
Locus tag XNC2_RS19450 Protein ID WP_013185754.1
Coordinates 4407195..4407506 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag XNC2_RS19445 Protein ID WP_013185753.1
Coordinates 4406779..4407198 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XNC2_RS19425 4403012..4404502 + 1491 WP_013185749.1 inorganic phosphate transporter PitA -
XNC2_RS19430 4404628..4404957 - 330 WP_010846191.1 universal stress protein UspB -
XNC2_RS19435 4405346..4406470 - 1125 Protein_3858 IS701 family transposase -
XNC2_RS19440 4406512..4406679 - 168 WP_013185752.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
XNC2_RS19445 4406779..4407198 - 420 WP_013185753.1 helix-turn-helix domain-containing protein Antitoxin
XNC2_RS19450 4407195..4407506 - 312 WP_013185754.1 type II toxin-antitoxin system HigB family toxin Toxin
XNC2_RS19455 4408079..4410151 - 2073 WP_013185755.1 phenylacetic acid degradation bifunctional protein PaaZ -
XNC2_RS19460 4410480..4411421 + 942 WP_010846184.1 1,2-phenylacetyl-CoA epoxidase subunit A -
XNC2_RS19465 4411492..4411779 + 288 WP_013185756.1 1,2-phenylacetyl-CoA epoxidase subunit B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12535.52 Da        Isoelectric Point: 10.0558

>T285560 WP_013185754.1 NZ_LN681227:c4407506-4407195 [Xenorhabdus nematophila AN6/1]
MHVISKEPFEQAVRDYPNDANVLITTYKLLKEKNFDSPLELQKLFPSLDNFKHRNKWWVIDIGGNNLRMIAYINFMNKRF
YVKHIVTHKEYDKLTKKYRETKE

Download         Length: 312 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15251.61 Da        Isoelectric Point: 5.6660

>AT285560 WP_013185753.1 NZ_LN681227:c4407198-4406779 [Xenorhabdus nematophila AN6/1]
MIREPIKALQATTALIAAVPFLGSSASEKDYRDALAMVDYLIENHDESPLINILAAKIAEYEDSNKRFAAFNKAVEVMPT
GVAALRVLMDQHGLSYSDLQEEIGSKSLISQIFSGKRALTIAHIKALSARFDVKPDIFL

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D3VFW9

Antitoxin

Source ID Structure

References