285559

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4076206..4077756 Replicon chromosome
Accession NZ_LN681227
Organism Xenorhabdus nematophila AN6/1

Toxin (Protein)


Gene name hipA Uniprot ID D3VDL4
Locus tag XNC2_RS17930 Protein ID WP_013185548.1
Coordinates 4076206..4077504 (-) Length 433 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID N1NPE2
Locus tag XNC2_RS17935 Protein ID WP_010847709.1
Coordinates 4077505..4077756 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XNC2_RS23055 4071956..4072466 - 511 Protein_3545 N-acetyltransferase -
XNC2_RS23060 4072450..4072623 - 174 WP_013185544.1 hypothetical protein -
XNC2_RS17915 4072667..4073359 - 693 WP_013185545.1 amino acid racemase -
XNC2_RS17920 4073488..4074378 + 891 WP_013185546.1 LysR family transcriptional regulator -
XNC2_RS17925 4074533..4075813 - 1281 WP_013185547.1 dicarboxylate/amino acid:cation symporter -
XNC2_RS17930 4076206..4077504 - 1299 WP_013185548.1 type II toxin-antitoxin system HipA family toxin Toxin
XNC2_RS17935 4077505..4077756 - 252 WP_010847709.1 helix-turn-helix domain-containing protein Antitoxin
XNC2_RS17940 4077860..4078597 + 738 Protein_3552 IS630 family transposase -
XNC2_RS17945 4078737..4079777 - 1041 WP_013185550.1 IS630 family transposase -
XNC2_RS17950 4080473..4081234 + 762 WP_013183573.1 IS5 family transposase -
XNC2_RS17955 4081200..4082483 - 1284 WP_013185552.1 serine hydroxymethyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4072040..4087789 15749
flank IS/Tn - - 4078737..4079777 1040


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(148-397)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 433 a.a.        Molecular weight: 48445.66 Da        Isoelectric Point: 6.9974

>T285559 WP_013185548.1 NZ_LN681227:c4077504-4076206 [Xenorhabdus nematophila AN6/1]
MNKLIVALNGLEVGVLFRDKKGAMSFQYTNEWLKEPGTRAISLSLPLSNQKYVGQEVFNFFDNLLPDSREIIARMQARFQ
ITSKHPFDLLASVGRDCVGAIQLYQEGNQIPPIDEVHAEPLDERAIVELLEGYKTTPLGMNNSDDFRISLAGAQEKTALL
WHQGCWQRPYGSTPTSHIFKLPIGRIEHNNIDLHESCENEWLCLKISRTFGLPVANAELAKFGEKTVLIVERFDRRWSCD
NRWLMRLPQEDMCQAMGIAPALKYEADGGPGIADIMTLLLGSRNSITDRETFFKSQILYWLLAAIDGHGKNFSIFIEPDS
SYSMTPLYDILSAYPIFGAKGVAPKKAKMAMALRGKSRQYHWATIQPRHFPSTARQVGFSESMAEKLMNEMGNMAEKVIN
QVANELPPNFPGHISDAIFTGLAKQAGRLCAG

Download         Length: 1299 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9479.82 Da        Isoelectric Point: 10.9422

>AT285559 WP_010847709.1 NZ_LN681227:c4077756-4077505 [Xenorhabdus nematophila AN6/1]
MKITSPQTLAVAIREQRKKKRLTQKDTADRVGIKQSTVSGFENSPEKSKLETLFKLLSSLGLELQVTERNGSTKSDSRWT
REW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D3VDL4

Antitoxin

Source ID Structure
AlphaFold DB N1NPE2

References