Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2148151..2148902 Replicon chromosome
Accession NZ_LN681227
Organism Xenorhabdus nematophila AN6/1

Toxin (Protein)


Gene name ataT Uniprot ID N1NQL5
Locus tag XNC2_RS09375 Protein ID WP_010845782.1
Coordinates 2148414..2148902 (+) Length 163 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID N1NPQ2
Locus tag XNC2_RS09370 Protein ID WP_010845781.1
Coordinates 2148151..2148423 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XNC2_RS09355 2144281..2144601 - 321 Protein_1846 IS110 family transposase -
XNC2_RS22190 2144588..2144842 + 255 Protein_1847 transposase -
XNC2_RS09360 2145315..2146076 - 762 WP_013184313.1 IS5 family transposase -
XNC2_RS09365 2146249..2147643 - 1395 WP_038218972.1 basic amino acid/polyamine antiporter -
XNC2_RS09370 2148151..2148423 + 273 WP_010845781.1 DUF1778 domain-containing protein Antitoxin
XNC2_RS09375 2148414..2148902 + 489 WP_010845782.1 GNAT family N-acetyltransferase Toxin
XNC2_RS09380 2149049..2150002 - 954 WP_013184314.1 DUF1471 domain-containing protein -
XNC2_RS09385 2150968..2152500 + 1533 WP_013184315.1 Re/Si-specific NAD(P)(+) transhydrogenase subunit alpha -
XNC2_RS09390 2152511..2153899 + 1389 WP_013184316.1 Re/Si-specific NAD(P)(+) transhydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2145315..2146076 761


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-145)

Antitoxin

Vibrio phage ICP1, Orf50

(5-89)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 18028.89 Da        Isoelectric Point: 9.0545

>T285553 WP_010845782.1 NZ_LN681227:2148414-2148902 [Xenorhabdus nematophila AN6/1]
VGISTPEILTVKHNVKDFYCQHETLNEWLSRRALKNNKLGASRTFVICKEGTKDVIGYYCLSAGSINHIESTPSLKRNMP
DAIPVMLLGRLAVDAEYQGKKLGALLLQDAWKRVASTAEQVGISAIIVHAFDESARTFYMRLGFVQSPLESYTLMLPLGK
QN

Download         Length: 489 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10497.99 Da        Isoelectric Point: 7.2775

>AT285553 WP_010845781.1 NZ_LN681227:2148151-2148423 [Xenorhabdus nematophila AN6/1]
MRTQPKETPINIRAKAFQRELIDHAANLHSKTRTDFILDAACRAAEEAILDQRHFFVNDEKYQAFMQMLEQPLSDNAGFK
KLMGYKAPWE

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N1NQL5

Antitoxin

Source ID Structure
AlphaFold DB N1NPQ2

References