Detailed information of TA system TA024798

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataRT/DUF1778(antitoxin)
• Location: 2148416..2149167
• Replicon: chromosome
• Accession: NC_014228
• Organism: Xenorhabdus nematophila ATCC 19061

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: N1NQL5
• Locus tag: XNC1_RS09365
• Protein ID: WP_010845782.1
• Coordinates: 2148679..2149167 (+)
• Length: 163 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: N1NPQ2
• Locus tag: XNC1_RS09360
• Protein ID: WP_010845781.1
• Coordinates: 2148416..2148688 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XNC1_RS09345 (XNC1_2216)	2144546..2144866	-	321	Protein_1847	IS110 family transposase	-
XNC1_RS22240 (XNC1_2217)	2144853..2145107	+	255	Protein_1848	transposase	-
XNC1_RS09350 (XNC1_2219)	2145580..2146341	-	762	WP_013184313.1	IS5 family transposase	-
XNC1_RS09355 (XNC1_2220)	2146514..2147908	-	1395	WP_038218972.1	basic amino acid/polyamine antiporter	-
XNC1_RS09360 (XNC1_2221)	2148416..2148688	+	273	WP_010845781.1	DUF1778 domain-containing protein	Antitoxin
XNC1_RS09365 (XNC1_2222)	2148679..2149167	+	489	WP_010845782.1	GNAT family N-acetyltransferase	Toxin
XNC1_RS09370 (XNC1_2223)	2149314..2150267	-	954	WP_013184314.1	DUF1471 domain-containing protein	-
XNC1_RS09375 (XNC1_2226)	2151233..2152765	+	1533	WP_013184315.1	Re/Si-specific NAD(P)(+) transhydrogenase subunit alpha	-
XNC1_RS09380 (XNC1_2227)	2152776..2154164	+	1389	WP_013184316.1	Re/Si-specific NAD(P)(+) transhydrogenase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NZ_LN681227 Xenorhabdus nematophila AN6/1 IS/Tn TA285553 2145315..2146076 0	flank	IS/Tn	-	-	2145580..2146341	761

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (44-145)

Antitoxin

• Vibrio phage ICP1, Orf50 (5-89)

Sequences

Toxin

Protein

• Length: 163 a.a.
• Molecular weight: 18028.89 Da
• Isoelectric Point: 9.0545

>T24798 WP_010845782.1 NC_014228:2148679-2149167 [Xenorhabdus nematophila ATCC 19061]
VGISTPEILTVKHNVKDFYCQHETLNEWLSRRALKNNKLGASRTFVICKEGTKDVIGYYCLSAGSINHIESTPSLKRNMP
DAIPVMLLGRLAVDAEYQGKKLGALLLQDAWKRVASTAEQVGISAIIVHAFDESARTFYMRLGFVQSPLESYTLMLPLGK
QN

Nucleotide

• Length: 489 bp

>T24798 NC_014228:2148679-2149167 [Xenorhabdus nematophila ATCC 19061]
GTGGGAATAAGTACGCCGGAAATCTTAACGGTTAAACATAATGTAAAGGATTTTTATTGCCAGCATGAAACATTAAACGA
ATGGCTTTCACGCCGGGCTTTAAAAAATAATAAGCTCGGCGCGAGCCGCACATTTGTTATTTGCAAGGAAGGAACAAAAG
ACGTTATCGGTTATTATTGTCTAAGTGCTGGTTCAATTAATCATATTGAATCTACACCATCCCTTAAACGCAATATGCCA
GATGCTATCCCTGTAATGTTGCTCGGCCGCCTAGCTGTTGATGCGGAATATCAGGGGAAGAAGCTCGGTGCATTACTTCT
TCAAGATGCTTGGAAGCGTGTTGCCAGTACGGCGGAACAGGTAGGCATTTCAGCGATAATTGTCCACGCATTTGATGAAA
GCGCCCGAACGTTCTATATGCGTCTTGGTTTCGTCCAGTCACCATTGGAGTCATATACACTGATGCTTCCATTAGGCAAA
CAGAACTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10497.99 Da
• Isoelectric Point: 7.2775

>AT24798 WP_010845781.1 NC_014228:2148416-2148688 [Xenorhabdus nematophila ATCC 19061]
MRTQPKETPINIRAKAFQRELIDHAANLHSKTRTDFILDAACRAAEEAILDQRHFFVNDEKYQAFMQMLEQPLSDNAGFK
KLMGYKAPWE

Nucleotide

• Length: 273 bp

>AT24798 NC_014228:2148416-2148688 [Xenorhabdus nematophila ATCC 19061]
ATGAGAACACAACCTAAAGAAACCCCGATTAACATCCGGGCGAAAGCCTTCCAGCGGGAGCTTATCGACCATGCAGCAAA
CCTACATTCGAAGACACGAACTGATTTCATCTTGGATGCTGCCTGCCGAGCTGCTGAAGAGGCCATACTCGATCAGCGCC
ACTTTTTTGTTAACGACGAAAAATATCAGGCGTTCATGCAGATGCTGGAACAACCGCTTTCTGATAACGCAGGTTTTAAA
AAGCTCATGGGATATAAAGCACCGTGGGAATAA

Structures

Toxin

• AlphaFold DB: N1NQL5

Antitoxin

• AlphaFold DB: N1NPQ2