Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 834578..835196 Replicon chromosome
Accession NZ_LN681227
Organism Xenorhabdus nematophila AN6/1

Toxin (Protein)


Gene name Hha Uniprot ID N1NUC1
Locus tag XNC2_RS04050 Protein ID WP_010845060.1
Coordinates 834993..835196 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID N1NQW2
Locus tag XNC2_RS04045 Protein ID WP_010845061.1
Coordinates 834578..834946 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XNC2_RS04035 829697..832846 + 3150 WP_013183588.1 multidrug efflux RND transporter permease subunit -
XNC2_RS04040 833025..834062 - 1038 WP_013183589.1 IS630 family transposase -
XNC2_RS04045 834578..834946 + 369 WP_010845061.1 Hha toxicity modulator TomB Antitoxin
XNC2_RS04050 834993..835196 + 204 WP_010845060.1 hemolysin expression modulator Hha Toxin
XNC2_RS04055 836024..836878 + 855 WP_013183591.1 acyl-CoA thioesterase II -
XNC2_RS04060 837053..838336 - 1284 WP_013183592.1 ammonium transporter AmtB -
XNC2_RS04065 838351..838689 - 339 WP_010845056.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integrative and Conjugative Element - acrB / lpxC 597760..1090208 492448


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8077.34 Da        Isoelectric Point: 6.9770

>T285551 WP_010845060.1 NZ_LN681227:834993-835196 [Xenorhabdus nematophila AN6/1]
MTKTDYLMRLRKCTSIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14490.38 Da        Isoelectric Point: 5.1920

>AT285551 WP_010845061.1 NZ_LN681227:834578-834946 [Xenorhabdus nematophila AN6/1]
MDEYSPKRYDIAELKYLCEKLIHEALSVLNRADSHWIHDLTSEKSLKLNELIEHIAAFVWNFKIKYTDHYDLSTLIDEYL
DETYNLFGSDKISFLELTKWQRTNEHLTNILLHDLNASLSKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N1NUC1

Antitoxin

Source ID Structure
AlphaFold DB N1NQW2

References