24796

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 834607..835225 Replicon chromosome
Accession NC_014228
Organism Xenorhabdus nematophila ATCC 19061

Toxin (Protein)


Gene name Hha Uniprot ID N1NUC1
Locus tag XNC1_RS04045 Protein ID WP_010845060.1
Coordinates 835022..835225 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID N1NQW2
Locus tag XNC1_RS04040 Protein ID WP_010845061.1
Coordinates 834607..834975 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XNC1_RS04030 (XNC1_0961) 829726..832875 + 3150 WP_013183588.1 multidrug efflux RND transporter permease subunit -
XNC1_RS04035 (XNC1_0962) 833054..834091 - 1038 WP_013183589.1 IS630 family transposase -
XNC1_RS04040 (XNC1_0963) 834607..834975 + 369 WP_010845061.1 Hha toxicity modulator TomB Antitoxin
XNC1_RS04045 (XNC1_0964) 835022..835225 + 204 WP_010845060.1 hemolysin expression modulator Hha Toxin
XNC1_RS04050 (XNC1_0967) 836053..836907 + 855 WP_013183591.1 acyl-CoA thioesterase II -
XNC1_RS04055 (XNC1_0968) 837082..838365 - 1284 WP_013183592.1 ammonium transporter AmtB -
XNC1_RS04060 (XNC1_0969) 838380..838718 - 339 WP_010845056.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integrative and Conjugative Element - acrB / lpxC 597788..1090259 492471


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8077.34 Da        Isoelectric Point: 6.9770

>T24796 WP_010845060.1 NC_014228:835022-835225 [Xenorhabdus nematophila ATCC 19061]
MTKTDYLMRLRKCTSIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 204 bp

>T24796 NC_014228:835022-835225 [Xenorhabdus nematophila ATCC 19061]
ATGACTAAAACTGACTATCTGATGCGTTTGAGAAAATGCACTTCTATTGAAACACTGGAACGTGTAATTGAAAAAAATAA
ATATGAACTTTCGGATGATGAACTTGAATTGTTCTACTCCGCTGCTGACCACCGTTTAGCCGAACTTACCATGAATAAAC
TCTATGATAAAATCCCATCATCTGTTTGGAAATTCGTCCGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14490.38 Da        Isoelectric Point: 5.1920

>AT24796 WP_010845061.1 NC_014228:834607-834975 [Xenorhabdus nematophila ATCC 19061]
MDEYSPKRYDIAELKYLCEKLIHEALSVLNRADSHWIHDLTSEKSLKLNELIEHIAAFVWNFKIKYTDHYDLSTLIDEYL
DETYNLFGSDKISFLELTKWQRTNEHLTNILLHDLNASLSKT

Download         Length: 369 bp

>AT24796 NC_014228:834607-834975 [Xenorhabdus nematophila ATCC 19061]
ATGGATGAATATTCACCAAAAAGATATGATATCGCTGAATTAAAATACTTGTGTGAAAAATTAATTCATGAGGCACTTTC
AGTCCTGAATCGCGCTGATAGTCACTGGATTCACGATCTGACTTCCGAGAAAAGCTTAAAATTAAACGAATTGATCGAAC
ACATTGCAGCTTTTGTCTGGAACTTTAAAATTAAATACACTGATCACTACGATCTCAGCACCTTAATTGATGAGTATCTG
GATGAAACATATAATTTGTTTGGAAGCGATAAGATAAGCTTTCTTGAACTTACTAAATGGCAAAGAACAAACGAACACTT
AACTAACATTCTGCTACATGATTTGAATGCTTCTTTAAGTAAAACCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N1NUC1

Antitoxin

Source ID Structure
AlphaFold DB N1NQW2

References