Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 100846..101496 Replicon chromosome
Accession NZ_LN681227
Organism Xenorhabdus nematophila AN6/1

Toxin (Protein)


Gene name higB Uniprot ID N1NNR7
Locus tag XNC2_RS00455 Protein ID WP_010847562.1
Coordinates 100846..101154 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag XNC2_RS00460 Protein ID WP_010847563.1
Coordinates 101200..101496 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XNC2_RS22535 96630..96767 + 138 WP_156148016.1 hypothetical protein -
XNC2_RS00435 96745..96963 + 219 Protein_83 Fic family protein -
XNC2_RS00440 97099..98085 - 987 WP_113967570.1 sulfate ABC transporter substrate-binding protein -
XNC2_RS00445 98388..99365 - 978 WP_013183083.1 6-phosphofructokinase -
XNC2_RS00450 99601..100500 - 900 WP_010847560.1 CDF family cation-efflux transporter FieF -
XNC2_RS00455 100846..101154 + 309 WP_010847562.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
XNC2_RS00460 101200..101496 + 297 WP_010847563.1 helix-turn-helix domain-containing protein Antitoxin
XNC2_RS00470 101831..102247 - 417 WP_010847564.1 type II toxin-antitoxin system HicB family antitoxin -
XNC2_RS00475 102302..102476 - 175 Protein_90 type II toxin-antitoxin system HicA family toxin -
XNC2_RS00480 102608..103051 - 444 WP_010847567.1 hypothetical protein -
XNC2_RS00485 103424..103924 - 501 WP_010847568.1 Spy/CpxP family protein refolding chaperone -
XNC2_RS00490 104077..104769 + 693 WP_013183086.1 envelope stress response regulator transcription factor CpxR -
XNC2_RS00495 104766..106148 + 1383 WP_013183087.1 envelope stress sensor histidine kinase CpxA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-101)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-92)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11887.92 Da        Isoelectric Point: 10.5016

>T285546 WP_010847562.1 NZ_LN681227:100846-101154 [Xenorhabdus nematophila AN6/1]
VYKRQVFSRERAELLTDDEFRHLQEHLLKNHEQGSTISATGGCKKIRLQREGMGKRGGVRIIYYTIIKTGMLYLLLIYPK
NKKDDLTPKQKEVLKAISNKLQ

Download         Length: 309 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11083.80 Da        Isoelectric Point: 7.3210

>AT285546 WP_010847563.1 NZ_LN681227:101200-101496 [Xenorhabdus nematophila AN6/1]
MDKKLFDDLIESMNQMVAIDKGELSVPAENIHRHRLPDVKKLRETFGLKQSEFAEAVGVSASLIQSWEQHRRTPSGSSLK
LLKMLERNPALINELSAL

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N1NNR7

Antitoxin

Source ID Structure

References