285441

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2037266..2037768 Replicon chromosome
Accession NZ_LM995446
Organism Escherichia coli strain K-12 substr. RV308

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag ECRV308_RS10290 Protein ID WP_000767829.1
Coordinates 2037266..2037520 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag ECRV308_RS10295 Protein ID WP_001259255.1
Coordinates 2037517..2037768 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECRV308_RS10265 2032281..2032508 - 228 WP_000234896.1 sulfurtransferase TusA -
ECRV308_RS10270 2032522..2033580 - 1059 WP_000492339.1 transport protein YeeE -
ECRV308_RS10275 2033759..2035117 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
ECRV308_RS25385 2035107..2035169 - 63 WP_010723108.1 membrane protein YoeI -
ECRV308_RS10280 2035384..2036313 - 930 WP_000803351.1 LysR family transcriptional regulator -
ECRV308_RS10285 2036359..2037183 - 825 WP_000754737.1 SDR family oxidoreductase -
ECRV308_RS10290 2037266..2037520 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
ECRV308_RS10295 2037517..2037768 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
ECRV308_RS23720 2038051..2038101 + 51 WP_001364200.1 his operon leader peptide -
ECRV308_RS10300 2038247..2039146 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
ECRV308_RS10305 2039152..2040456 + 1305 WP_000009594.1 histidinol dehydrogenase -
ECRV308_RS10310 2040453..2041523 + 1071 WP_000108941.1 histidinol-phosphate transaminase -
ECRV308_RS10315 2041523..2042590 + 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T285441 WP_000767829.1 NZ_LM995446:c2037520-2037266 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT285441 WP_001259255.1 NZ_LM995446:c2037768-2037517 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References