Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3120231..3120924 Replicon chromosome
Accession NZ_LM993812
Organism Escherichia coli strain K-12 substr. HMS174

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag ECHMS174_RS15420 Protein ID WP_000415584.1
Coordinates 3120628..3120924 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag ECHMS174_RS15415 Protein ID WP_000650107.1
Coordinates 3120231..3120626 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECHMS174_RS15405 3116095..3118353 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
ECHMS174_RS15410 3118491..3120098 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
ECHMS174_RS15415 3120231..3120626 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
ECHMS174_RS15420 3120628..3120924 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
ECHMS174_RS15425 3121129..3121611 - 483 WP_000183505.1 transcriptional regulator -
ECHMS174_RS15430 3121664..3122056 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
ECHMS174_RS15435 3122208..3122867 + 660 WP_001221495.1 two-component system response regulator QseB -
ECHMS174_RS15440 3122864..3124213 + 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
ECHMS174_RS15445 3124259..3124591 - 333 WP_000917684.1 DUF2645 family protein -
ECHMS174_RS15450 3124910..3125491 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
ECHMS174_RS15455 3125522..3125836 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T285410 WP_000415584.1 NZ_LM993812:c3120924-3120628 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT285410 WP_000650107.1 NZ_LM993812:c3120626-3120231 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References