Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2040818..2041320 Replicon chromosome
Accession NZ_LM993812
Organism Escherichia coli strain K-12 substr. HMS174

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag ECHMS174_RS10260 Protein ID WP_000767829.1
Coordinates 2040818..2041072 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag ECHMS174_RS10265 Protein ID WP_001259255.1
Coordinates 2041069..2041320 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECHMS174_RS10235 2035833..2036060 - 228 WP_000234896.1 sulfurtransferase TusA -
ECHMS174_RS10240 2036074..2037132 - 1059 WP_000492339.1 transport protein YeeE -
ECHMS174_RS10245 2037311..2038669 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
ECHMS174_RS25395 2038659..2038721 - 63 WP_010723108.1 membrane protein YoeI -
ECHMS174_RS10250 2038936..2039865 - 930 WP_000803351.1 LysR family transcriptional regulator -
ECHMS174_RS10255 2039911..2040735 - 825 WP_000754737.1 SDR family oxidoreductase -
ECHMS174_RS10260 2040818..2041072 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
ECHMS174_RS10265 2041069..2041320 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
ECHMS174_RS23710 2041603..2041653 + 51 WP_001364200.1 his operon leader peptide -
ECHMS174_RS10270 2041799..2042698 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
ECHMS174_RS10275 2042704..2044008 + 1305 WP_000009594.1 histidinol dehydrogenase -
ECHMS174_RS10280 2044005..2045075 + 1071 WP_000108941.1 histidinol-phosphate transaminase -
ECHMS174_RS10285 2045075..2046142 + 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T285405 WP_000767829.1 NZ_LM993812:c2041072-2040818 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT285405 WP_001259255.1 NZ_LM993812:c2041320-2041069 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References