Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1443547..1444202 Replicon chromosome
Accession NZ_LK937696
Organism Coxiella burnetii Z3055

Toxin (Protein)


Gene name graT Uniprot ID Q83BL3
Locus tag TY29_RS07605 Protein ID WP_010958264.1
Coordinates 1443864..1444202 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag TY29_RS07600 Protein ID WP_010958263.1
Coordinates 1443547..1443858 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TY29_RS07575 1438823..1439500 - 678 WP_010958258.1 cyclin -
TY29_RS07585 1439819..1441201 - 1383 WP_010958260.1 cysteine--tRNA ligase -
TY29_RS07590 1441192..1442589 - 1398 WP_010958261.1 glutamate--tRNA ligase -
TY29_RS07595 1442746..1443478 + 733 Protein_1449 UDP-2,3-diacylglucosamine diphosphatase -
TY29_RS07600 1443547..1443858 - 312 WP_010958263.1 HigA family addiction module antidote protein Antitoxin
TY29_RS07605 1443864..1444202 - 339 WP_010958264.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
TY29_RS07610 1444561..1445707 + 1147 Protein_1452 ISAs1 family transposase -
TY29_RS07615 1446035..1447708 + 1674 WP_012220680.1 CBU_1493 family Dot/Icm T4SS effector -
TY29_RS07620 1447874..1448605 - 732 WP_041952479.1 pyridoxine 5'-phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1444616..1445707 1091


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(23-112)

Antitoxin

Cro/C1-type helix-turn-helix domain

(26-72)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13409.66 Da        Isoelectric Point: 10.4588

>T285387 WP_010958264.1 NZ_LK937696:c1444202-1443864 [Coxiella burnetii Z3055]
MPLTLYIMLDVTRKTVILEVIIKSFKDKYTKYLYKGVSVSKWQAIRKQAERRLQILDSVTSLDDLRSLPSNRFESLRGNR
KGQFSIRINKQWRICFKWINNEPTEVEIVDYH

Download         Length: 339 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11458.39 Da        Isoelectric Point: 10.1699

>AT285387 WP_010958263.1 NZ_LK937696:c1443858-1443547 [Coxiella burnetii Z3055]
MKMAANRMRPIHPGEILAEELGFLDKMSANQLAKHLAIPTNRVTAILNGARSITADTALRLAKFFGTTPEFWLNLQDAYD
IKMALKKSGKKIEKEVTPYDQAA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q83BL3

Antitoxin

Source ID Structure

References