Detailed information of TA system TA285366

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2743..3322
• Replicon: chromosome
• Accession: NZ_JPPU01000009
• Organism: Staphylococcus aureus strain HG003 isolate RN1 Scaffold_9

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: Q2FY92
• Locus tag: IM26_RS21120
• Protein ID: WP_001025402.1
• Coordinates: 2743..2988 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2957..3322 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IM26_RS0114270	1..119	-	119	WP_031926752.1	hypothetical protein	-
IM26_RS21100 (IM26_06135)	323..664	-	342	WP_000591749.1	hypothetical protein	-
IM26_RS21105 (IM26_06140)	670..1602	-	933	WP_000759682.1	exonuclease domain-containing protein	-
IM26_RS21110 (IM26_06145)	1618..2331	-	714	WP_001031454.1	XRE family transcriptional regulator	-
IM26_RS0114275	2294..2467	+	174	WP_001801500.1	hypothetical protein	-
IM26_RS21115 (IM26_06150)	2464..2727	+	264	WP_000854072.1	helix-turn-helix transcriptional regulator	-
IM26_RS21120 (IM26_06155)	2743..2988	+	246	WP_001025402.1	DUF2829 domain-containing protein	Toxin
IM26_RS21125 (IM26_06160)	2957..3322	-	366	WP_001131647.1	hypothetical protein	Antitoxin
IM26_RS21130 (IM26_06165)	3377..3592	+	216	WP_001097552.1	hypothetical protein	-
IM26_RS21135 (IM26_06170)	3617..3880	+	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
IM26_RS0114280	3893..4054	+	162	WP_001285961.1	DUF1270 domain-containing protein	-
IM26_RS21140 (IM26_06180)	4133..4456	+	324	WP_000174996.1	hypothetical protein	-
IM26_RS21145 (IM26_06185)	4471..4833	+	363	WP_000279452.1	hypothetical protein	-
IM26_RS21150 (IM26_06190)	4830..5996	+	1167	WP_000762540.1	DUF2800 domain-containing protein	-
IM26_RS21155 (IM26_06195)	6022..6579	+	558	WP_000645042.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	323..43936	43613

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9434.70 Da
• Isoelectric Point: 5.7783

>T285366 WP_001025402.1 NZ_JPPU01000009:2743-2988 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
L

Nucleotide

• Length: 246 bp

>T285366 NZ_JPPU01000009:2743-2988 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTATAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT285366 NZ_JPPU01000009:c3322-2957 [Staphylococcus aureus]
ATGCCCTTGACATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGATTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTATAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: Q2FY92

Antitoxin