Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4734563..4735152 Replicon chromosome
Accession NZ_HG999364
Organism Xanthomonas euroxanthea isolate Xanthomonas euroxanthea CPBF 766 isolated from C. illinoinensis

Toxin (Protein)


Gene name graT Uniprot ID A0A2S7AZR2
Locus tag KHO05_RS20195 Protein ID WP_039429225.1
Coordinates 4734871..4735152 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag KHO05_RS20190 Protein ID WP_184630970.1
Coordinates 4734563..4734853 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHO05_RS20160 (XCY_004024) 4730040..4730654 - 615 WP_212580452.1 hypothetical protein -
KHO05_RS20165 (XCY_004025) 4730754..4731395 - 642 WP_212580453.1 MAE_28990/MAE_18760 family HEPN-like nuclease -
KHO05_RS20170 (XCY_004026) 4731392..4732318 - 927 WP_244813306.1 DUF262 domain-containing protein -
KHO05_RS20175 (XCY_004027) 4732780..4733112 + 333 Protein_3959 hypothetical protein -
KHO05_RS20605 4733262..4733464 + 203 Protein_3960 hypothetical protein -
KHO05_RS20180 (XCY_004028) 4733537..4733929 - 393 WP_212580454.1 hypothetical protein -
KHO05_RS20185 (XCY_004029) 4733926..4734465 - 540 WP_244813206.1 hypothetical protein -
KHO05_RS20190 (XCY_004030) 4734563..4734853 - 291 WP_184630970.1 HigA family addiction module antitoxin Antitoxin
KHO05_RS20195 (XCY_004031) 4734871..4735152 - 282 WP_039429225.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KHO05_RS20200 (XCY_004032) 4735366..4735620 + 255 WP_176340353.1 antitoxin -
KHO05_RS20610 4735620..4735730 + 111 Protein_3966 type II toxin-antitoxin system RelE/ParE family toxin -
KHO05_RS20210 (XCY_004034) 4735728..4736240 - 513 WP_244813208.1 hypothetical protein -
KHO05_RS20215 (XCY_004035) 4736573..4738987 - 2415 WP_212580456.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4721756..4736240 14484


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11046.72 Da        Isoelectric Point: 9.7972

>T285352 WP_039429225.1 NZ_HG999364:c4735152-4734871 [Xanthomonas euroxanthea]
MIRSFVDKEAEKIWLGERSRRLPADIQSVARRKLRMLNAAAHLDDLRIPPANRLEALKGERRGQYSIRINDQWRICFRWM
EGDVAEVEIVDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10468.13 Da        Isoelectric Point: 7.2043

>AT285352 WP_184630970.1 NZ_HG999364:c4734853-4734563 [Xanthomonas euroxanthea]
MTVLPNIHPGEVLLEEFLEPMGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTTERFWLGLQADYELEQA
HRALGDLPSRIKRLAA

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S7AZR2

Antitoxin

Source ID Structure

References