Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4917470..4918072 Replicon chromosome
Accession NZ_HG994851
Organism Escherichia coli isolate 127

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag LLO82_RS23720 Protein ID WP_000897305.1
Coordinates 4917761..4918072 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LLO82_RS23715 Protein ID WP_000356397.1
Coordinates 4917470..4917760 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLO82_RS23695 (4913972) 4913972..4914874 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
LLO82_RS23700 (4914871) 4914871..4915506 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
LLO82_RS23705 (4915503) 4915503..4916432 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
LLO82_RS23710 (4916647) 4916647..4916865 - 219 WP_001298592.1 CopG family transcriptional regulator -
LLO82_RS23715 (4917470) 4917470..4917760 - 291 WP_000356397.1 NadS family protein Antitoxin
LLO82_RS23720 (4917761) 4917761..4918072 - 312 WP_000897305.1 hypothetical protein Toxin
LLO82_RS23725 (4918301) 4918301..4919209 + 909 WP_001298596.1 alpha/beta hydrolase -
LLO82_RS23730 (4919273) 4919273..4920214 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
LLO82_RS23735 (4920259) 4920259..4920696 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
LLO82_RS23740 (4920693) 4920693..4921565 - 873 WP_000920762.1 virulence factor BrkB family protein -
LLO82_RS23745 (4921559) 4921559..4922158 - 600 WP_001298594.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12172.16 Da        Isoelectric Point: 9.7791

>T285338 WP_000897305.1 NZ_HG994851:c4918072-4917761 [Escherichia coli]
ILFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT285338 WP_000356397.1 NZ_HG994851:c4917760-4917470 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References