Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4308622..4309034 Replicon chromosome
Accession NZ_HG994851
Organism Escherichia coli isolate 127

Toxin (Protein)


Gene name symE Uniprot ID S1NWQ7
Locus tag LLO82_RS20885 Protein ID WP_000132614.1
Coordinates 4308693..4309034 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4308622..4308698 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLO82_RS20875 (4305297) 4305297..4306766 + 1470 WP_001540814.1 type I restriction-modification system subunit M -
LLO82_RS20880 (4306766) 4306766..4308472 + 1707 WP_001100194.1 restriction endonuclease subunit S -
- (4308622) 4308622..4308698 - 77 NuclAT_6 - Antitoxin
- (4308622) 4308622..4308698 - 77 NuclAT_6 - Antitoxin
- (4308622) 4308622..4308698 - 77 NuclAT_6 - Antitoxin
- (4308622) 4308622..4308698 - 77 NuclAT_6 - Antitoxin
- (4308622) 4308622..4308698 - 77 NuclAT_7 - Antitoxin
- (4308622) 4308622..4308698 - 77 NuclAT_7 - Antitoxin
- (4308622) 4308622..4308698 - 77 NuclAT_7 - Antitoxin
- (4308622) 4308622..4308698 - 77 NuclAT_7 - Antitoxin
LLO82_RS20885 (4308693) 4308693..4309034 + 342 WP_000132614.1 endoribonuclease SymE Toxin
LLO82_RS20890 (4309081) 4309081..4310244 - 1164 WP_072002093.1 DUF1524 domain-containing protein -
LLO82_RS20895 (4310292) 4310292..4311174 - 883 Protein_4094 DUF262 domain-containing protein -
LLO82_RS20905 (4311364) 4311364..4311441 + 78 Protein_4095 hypothetical protein -
LLO82_RS20910 (4311580) 4311580..4312500 - 921 WP_000181195.1 Rpn family recombination-promoting nuclease/putative transposase -
LLO82_RS20915 (4312685) 4312685..4313965 + 1281 WP_001298033.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - cheD 4292501..4311237 18736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12266.07 Da        Isoelectric Point: 8.4982

>T285332 WP_000132614.1 NZ_HG994851:4308693-4309034 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT285332 NZ_HG994851:c4308698-4308622 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NWQ7

Antitoxin

Download structure file

References