Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4183398..4183656 Replicon chromosome
Accession NZ_HG994851
Organism Escherichia coli isolate 127

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag LLO82_RS20215 Protein ID WP_000809168.1
Coordinates 4183504..4183656 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4183398..4183455 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLO82_RS20200 4179227..4180486 - 1260 WP_000494927.1 hypothetical protein -
LLO82_RS20205 4180615..4182108 - 1494 WP_001314416.1 sulfatase-like hydrolase/transferase -
LLO82_RS20210 4182128..4182889 - 762 WP_001274828.1 outer membrane protein OmpK -
- 4183398..4183455 - 58 - - Antitoxin
LLO82_RS20215 4183504..4183656 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
LLO82_RS20220 4183761..4184891 - 1131 WP_001118464.1 molecular chaperone DnaJ -
LLO82_RS20225 4184980..4186896 - 1917 WP_000516135.1 molecular chaperone DnaK -
LLO82_RS20230 4187268..4187672 + 405 WP_000843689.1 DUF2541 family protein -
LLO82_RS20235 4187698..4188411 + 714 WP_001102393.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T285331 WP_000809168.1 NZ_HG994851:4183504-4183656 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT285331 NZ_HG994851:c4183455-4183398 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References