Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1929700..1930202 Replicon chromosome
Accession NZ_HG994851
Organism Escherichia coli isolate 127

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag LLO82_RS09120 Protein ID WP_000767822.1
Coordinates 1929948..1930202 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag LLO82_RS09115 Protein ID WP_001259255.1
Coordinates 1929700..1929951 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLO82_RS09090 (1924878) 1924878..1925945 - 1068 WP_000080122.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
LLO82_RS09095 (1925945) 1925945..1927015 - 1071 WP_000108995.1 histidinol-phosphate transaminase -
LLO82_RS09100 (1927012) 1927012..1928316 - 1305 WP_001297912.1 histidinol dehydrogenase -
LLO82_RS09105 (1928322) 1928322..1929221 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
LLO82_RS09110 (1929367) 1929367..1929417 - 51 WP_001364200.1 his operon leader peptide -
LLO82_RS09115 (1929700) 1929700..1929951 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
LLO82_RS09120 (1929948) 1929948..1930202 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
LLO82_RS09125 (1930285) 1930285..1931109 + 825 WP_000754733.1 SDR family oxidoreductase -
LLO82_RS09130 (1931155) 1931155..1932084 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
LLO82_RS09135 (1932299) 1932299..1932361 + 63 WP_010723108.1 membrane protein YoeI -
LLO82_RS09140 (1932351) 1932351..1933709 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T285316 WP_000767822.1 NZ_HG994851:1929948-1930202 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT285316 WP_001259255.1 NZ_HG994851:1929700-1929951 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References