Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4970323..4970925 Replicon chromosome
Accession NZ_HG994850
Organism Escherichia coli isolate 127

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag LLO83_RS23930 Protein ID WP_000897305.1
Coordinates 4970614..4970925 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LLO83_RS23925 Protein ID WP_000356397.1
Coordinates 4970323..4970613 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLO83_RS23905 (4966825) 4966825..4967727 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
LLO83_RS23910 (4967724) 4967724..4968359 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
LLO83_RS23915 (4968356) 4968356..4969285 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
LLO83_RS23920 (4969500) 4969500..4969718 - 219 WP_001298592.1 CopG family transcriptional regulator -
LLO83_RS23925 (4970323) 4970323..4970613 - 291 WP_000356397.1 NadS family protein Antitoxin
LLO83_RS23930 (4970614) 4970614..4970925 - 312 WP_000897305.1 hypothetical protein Toxin
LLO83_RS23935 (4971154) 4971154..4972062 + 909 WP_001298596.1 alpha/beta hydrolase -
LLO83_RS23940 (4972126) 4972126..4973067 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
LLO83_RS23945 (4973112) 4973112..4973549 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
LLO83_RS23950 (4973546) 4973546..4974418 - 873 WP_000920762.1 virulence factor BrkB family protein -
LLO83_RS23955 (4974412) 4974412..4975011 - 600 WP_001298594.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12172.16 Da        Isoelectric Point: 9.7791

>T285310 WP_000897305.1 NZ_HG994850:c4970925-4970614 [Escherichia coli]
ILFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT285310 WP_000356397.1 NZ_HG994850:c4970613-4970323 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References