Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4361475..4361887 Replicon chromosome
Accession NZ_HG994850
Organism Escherichia coli isolate 127

Toxin (Protein)


Gene name symE Uniprot ID S1NWQ7
Locus tag LLO83_RS21095 Protein ID WP_000132614.1
Coordinates 4361546..4361887 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4361475..4361551 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLO83_RS21085 (4358150) 4358150..4359619 + 1470 WP_001540814.1 type I restriction-modification system subunit M -
LLO83_RS21090 (4359619) 4359619..4361325 + 1707 WP_001100194.1 restriction endonuclease subunit S -
- (4361475) 4361475..4361551 - 77 NuclAT_6 - Antitoxin
- (4361475) 4361475..4361551 - 77 NuclAT_6 - Antitoxin
- (4361475) 4361475..4361551 - 77 NuclAT_6 - Antitoxin
- (4361475) 4361475..4361551 - 77 NuclAT_6 - Antitoxin
- (4361475) 4361475..4361551 - 77 NuclAT_7 - Antitoxin
- (4361475) 4361475..4361551 - 77 NuclAT_7 - Antitoxin
- (4361475) 4361475..4361551 - 77 NuclAT_7 - Antitoxin
- (4361475) 4361475..4361551 - 77 NuclAT_7 - Antitoxin
LLO83_RS21095 (4361546) 4361546..4361887 + 342 WP_000132614.1 endoribonuclease SymE Toxin
LLO83_RS21100 (4361934) 4361934..4363097 - 1164 WP_072002093.1 DUF1524 domain-containing protein -
LLO83_RS21105 (4363145) 4363145..4364027 - 883 Protein_4136 DUF262 domain-containing protein -
LLO83_RS21115 (4364217) 4364217..4364294 + 78 Protein_4137 hypothetical protein -
LLO83_RS21120 (4364433) 4364433..4365353 - 921 WP_000181195.1 Rpn family recombination-promoting nuclease/putative transposase -
LLO83_RS21125 (4365538) 4365538..4366818 + 1281 WP_001298033.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - cheD 4345354..4364090 18736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12266.07 Da        Isoelectric Point: 8.4982

>T285304 WP_000132614.1 NZ_HG994850:4361546-4361887 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT285304 NZ_HG994850:c4361551-4361475 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NWQ7

Antitoxin

Download structure file

References