Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4236251..4236509 Replicon chromosome
Accession NZ_HG994850
Organism Escherichia coli isolate 127

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag LLO83_RS20425 Protein ID WP_000809168.1
Coordinates 4236357..4236509 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4236251..4236308 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLO83_RS20410 4232080..4233339 - 1260 WP_000494927.1 hypothetical protein -
LLO83_RS20415 4233468..4234961 - 1494 WP_001314416.1 sulfatase-like hydrolase/transferase -
LLO83_RS20420 4234981..4235742 - 762 WP_001274828.1 outer membrane protein OmpK -
- 4236251..4236308 - 58 - - Antitoxin
LLO83_RS20425 4236357..4236509 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
LLO83_RS20430 4236614..4237744 - 1131 WP_001118464.1 molecular chaperone DnaJ -
LLO83_RS20435 4237833..4239749 - 1917 WP_000516135.1 molecular chaperone DnaK -
LLO83_RS20440 4240121..4240525 + 405 WP_000843689.1 DUF2541 family protein -
LLO83_RS20445 4240551..4241264 + 714 WP_001102393.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T285303 WP_000809168.1 NZ_HG994850:4236357-4236509 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT285303 NZ_HG994850:c4236308-4236251 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References