Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1950056..1950558 Replicon chromosome
Accession NZ_HG994850
Organism Escherichia coli isolate 127

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag LLO83_RS09190 Protein ID WP_000767822.1
Coordinates 1950304..1950558 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag LLO83_RS09185 Protein ID WP_001259255.1
Coordinates 1950056..1950307 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLO83_RS09160 (1945234) 1945234..1946301 - 1068 WP_000080122.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
LLO83_RS09165 (1946301) 1946301..1947371 - 1071 WP_000108995.1 histidinol-phosphate transaminase -
LLO83_RS09170 (1947368) 1947368..1948672 - 1305 WP_001297912.1 histidinol dehydrogenase -
LLO83_RS09175 (1948678) 1948678..1949577 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
LLO83_RS09180 (1949723) 1949723..1949773 - 51 WP_001364200.1 his operon leader peptide -
LLO83_RS09185 (1950056) 1950056..1950307 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
LLO83_RS09190 (1950304) 1950304..1950558 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
LLO83_RS09195 (1950641) 1950641..1951465 + 825 WP_000754733.1 SDR family oxidoreductase -
LLO83_RS09200 (1951511) 1951511..1952440 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
LLO83_RS09205 (1952655) 1952655..1952717 + 63 WP_010723108.1 membrane protein YoeI -
LLO83_RS09210 (1952707) 1952707..1954065 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T285288 WP_000767822.1 NZ_HG994850:1950304-1950558 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT285288 WP_001259255.1 NZ_HG994850:1950056-1950307 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References