Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 608586..609385 Replicon chromosome
Accession NZ_HG994850
Organism Escherichia coli isolate 127

Toxin (Protein)


Gene name yhaV Uniprot ID Q8FDB4
Locus tag LLO83_RS02970 Protein ID WP_000347252.1
Coordinates 608586..609050 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag LLO83_RS02975 Protein ID WP_001296435.1
Coordinates 609050..609385 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLO83_RS02940 (603587) 603587..604021 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
LLO83_RS02945 (604039) 604039..604917 - 879 WP_001298314.1 PTS N-acetylgalactosamine transporter subunit IID -
LLO83_RS02950 (604907) 604907..605686 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
LLO83_RS02955 (605697) 605697..606170 - 474 WP_001298322.1 PTS N-acetylgalactosamine transporter subunit IIB -
LLO83_RS02960 (606193) 606193..607473 - 1281 WP_000681930.1 tagatose-bisphosphate aldolase subunit KbaZ -
LLO83_RS02965 (607722) 607722..608531 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
LLO83_RS02970 (608586) 608586..609050 - 465 WP_000347252.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
LLO83_RS02975 (609050) 609050..609385 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
LLO83_RS02980 (609534) 609534..611105 - 1572 WP_001273939.1 galactarate dehydratase -
LLO83_RS02985 (611480) 611480..612814 + 1335 WP_000979025.1 galactarate/glucarate/glycerate transporter GarP -
LLO83_RS02990 (612830) 612830..613600 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17750.11 Da        Isoelectric Point: 9.4947

>T285284 WP_000347252.1 NZ_HG994850:c609050-608586 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEESH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT285284 WP_001296435.1 NZ_HG994850:c609385-609050 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8FDB4

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References