285246

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 476496..477095 Replicon chromosome
Accession NZ_HG969192
Organism Bartonella tribocorum strain BM1374166

Toxin (Protein)


Gene name higB Uniprot ID A0A5B9CYQ5
Locus tag BM1374166_RS01935 Protein ID WP_012230946.1
Coordinates 476496..476777 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BM1374166_RS01940 Protein ID WP_012230948.1
Coordinates 476796..477095 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BM1374166_RS01905 471999..472406 + 408 WP_012230938.1 hypothetical protein -
BM1374166_RS01910 472483..473871 + 1389 WP_012230940.1 hypothetical protein -
BM1374166_RS01915 473868..474281 + 414 WP_012230942.1 hypothetical protein -
BM1374166_RS01920 474358..475281 + 924 WP_038473276.1 hypothetical protein -
BM1374166_RS01925 475343..475804 + 462 WP_081458175.1 hypothetical protein -
BM1374166_RS01930 475801..476214 + 414 WP_012230944.1 hypothetical protein -
BM1374166_RS01935 476496..476777 + 282 WP_012230946.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BM1374166_RS01940 476796..477095 + 300 WP_012230948.1 HigA family addiction module antidote protein Antitoxin
BM1374166_RS01945 477153..478190 - 1038 WP_012230950.1 tyrosine-type recombinase/integrase -
BM1374166_RS01950 478193..478441 - 249 WP_012230952.1 hypothetical protein -
BM1374166_RS01955 478553..479176 - 624 WP_012230954.1 YqaJ viral recombinase family protein -
BM1374166_RS01960 479178..479984 - 807 WP_038473282.1 ERF family protein -
BM1374166_RS01965 480058..480600 - 543 WP_012230958.1 hypothetical protein -
BM1374166_RS01970 480594..481085 - 492 WP_012230960.1 hypothetical protein -
BM1374166_RS01975 481089..481703 - 615 WP_012230962.1 hypothetical protein -
BM1374166_RS01980 481715..482032 - 318 WP_012230964.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(2-89)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10675.46 Da        Isoelectric Point: 10.2972

>T285246 WP_012230946.1 NZ_HG969192:476496-476777 [Bartonella tribocorum]
MAIVSFKHKGLKLFYTTGSTKAIRPDHVKKLRVILTALTSATTPDMLRAPAFKMHPLKGELTGYYSIWVNGNWRVTFRFI
GTDVELVDYQDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11112.87 Da        Isoelectric Point: 6.9876

>AT285246 WP_012230948.1 NZ_HG969192:476796-477095 [Bartonella tribocorum]
MMHNPAHPGEVLKVAFLEEMGITIQKLADHLHMTRASLSRVINGHASISTELAIKLELAGFSKAKFWLDMQTNYNLWQTM
QQTQPPISPLVSDVSQTQL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5B9CYQ5

Antitoxin

Source ID Structure

References