Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 382678..383305 Replicon chromosome
Accession NZ_HG969191
Organism Bartonella henselae strain BM1374165

Toxin (Protein)


Gene name higB Uniprot ID X5MEM9
Locus tag BM1374165_RS01560 Protein ID WP_038487056.1
Coordinates 382678..382992 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag BM1374165_RS01565 Protein ID WP_034454130.1
Coordinates 383009..383305 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BM1374165_RS01540 378314..379858 - 1545 WP_038487050.1 phage portal protein -
BM1374165_RS01545 379858..380106 - 249 WP_038487052.1 phage related protein -
BM1374165_RS01550 380110..382041 - 1932 WP_038487054.1 phage terminase large subunit family protein -
BM1374165_RS01555 382034..382615 - 582 WP_038488823.1 hypothetical protein -
BM1374165_RS01560 382678..382992 + 315 WP_038487056.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BM1374165_RS01565 383009..383305 + 297 WP_034454130.1 HigA family addiction module antidote protein Antitoxin
BM1374165_RS01570 383714..383977 + 264 WP_038487057.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
BM1374165_RS01575 383964..384245 + 282 WP_011180281.1 type II toxin-antitoxin system YafQ family toxin -
BM1374165_RS01580 384288..384566 - 279 WP_038487059.1 hypothetical protein -
BM1374165_RS01585 384563..385321 - 759 WP_038487061.1 antA/AntB antirepressor family protein -
BM1374165_RS01590 385616..386179 - 564 Protein_300 antA/AntB antirepressor family protein -
BM1374165_RS01595 386757..387347 - 591 WP_038487063.1 antA/AntB antirepressor family protein -
BM1374165_RS01600 387675..388253 - 579 WP_038487065.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 361130..408510 47380


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(12-104)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-80)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12135.97 Da        Isoelectric Point: 9.0878

>T285229 WP_038487056.1 NZ_HG969191:382678-382992 [Bartonella henselae]
MIHKRTNEGDLVIESFADKRCKDLLEGNPPKGFPTTLVRIVQRKLFMLDKAVDLKDLRSPPGNRLDALKGERKGQYSIRI
NDQFRICFEWRSNGAYEVEIIDYH

Download         Length: 315 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11265.91 Da        Isoelectric Point: 5.1546

>AT285229 WP_034454130.1 NZ_HG969191:383009-383305 [Bartonella henselae]
MKNYIAIHPGEILREEYLKEYALSAYALAKALNVPRTRIERIVAENSPVTPDTALRLAYFFDTTAEFWLNMQAAYDVSVL
QAEKADEFSKISKFECRV

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5MEM9

Antitoxin

Source ID Structure

References