Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 406071..406698 Replicon chromosome
Accession NZ_HG965802
Organism Bartonella henselae strain BM1374163

Toxin (Protein)


Gene name higB Uniprot ID A0A0H3M2H0
Locus tag PRJBM_RS01655 Protein ID WP_011180277.1
Coordinates 406071..406385 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag PRJBM_RS01660 Protein ID WP_011180278.1
Coordinates 406402..406698 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PRJBM_RS01635 401698..403254 - 1557 WP_011180273.1 phage portal protein -
PRJBM_RS01640 403254..403502 - 249 WP_011180274.1 hypothetical protein -
PRJBM_RS01645 403506..405434 - 1929 WP_011180275.1 phage terminase large subunit family protein -
PRJBM_RS01650 405427..406008 - 582 WP_011180276.1 hypothetical protein -
PRJBM_RS01655 406071..406385 + 315 WP_011180277.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PRJBM_RS01660 406402..406698 + 297 WP_011180278.1 HigA family addiction module antidote protein Antitoxin
PRJBM_RS01665 407108..407371 + 264 WP_011180280.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
PRJBM_RS01670 407358..407639 + 282 WP_011180281.1 type II toxin-antitoxin system YafQ family toxin -
PRJBM_RS01675 407682..407960 - 279 WP_011180242.1 hypothetical protein -
PRJBM_RS01680 407957..408715 - 759 WP_011180282.1 phage antirepressor Ant -
PRJBM_RS01685 408775..409290 - 516 WP_011180283.1 phage antirepressor Ant -
PRJBM_RS01690 409583..410146 - 564 Protein_328 antA/AntB antirepressor family protein -
PRJBM_RS01695 410178..410720 - 543 WP_011180285.1 phage antirepressor Ant -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 362344..432004 69660


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(15-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-67)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12135.97 Da        Isoelectric Point: 9.0878

>T285220 WP_011180277.1 NZ_HG965802:406071-406385 [Bartonella henselae]
MIHKRTNEGDLVIESFADKRCKDLLEGNPPKGFPTTLVRIVQRKLFMLDKAVDLKDLRSPPGNRLEALKGERKGQYSIRI
NDQFRICFEWRSNGAYEVEIVDYH

Download         Length: 315 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11262.91 Da        Isoelectric Point: 5.8690

>AT285220 WP_011180278.1 NZ_HG965802:406402-406698 [Bartonella henselae]
MKNYIAIHPGEILREEYLKEYALSAYALAKALNVPRTRIERIVAENSRITPDTALRLASFFDTTAEFWLNMQAAYDVSVL
QAEKADEFSKISKFECRV

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3M2H0

Antitoxin

Source ID Structure

References