Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4451911..4452513 Replicon chromosome
Accession NZ_HG941718
Organism Escherichia coli O25b:H4-ST131 strain EC958

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag EC958_RS22340 Protein ID WP_000897302.1
Coordinates 4451911..4452222 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EC958_RS22345 Protein ID WP_000356397.1
Coordinates 4452223..4452513 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC958_RS22315 4447825..4448424 + 600 WP_001296610.1 glucose-1-phosphatase -
EC958_RS22320 4448418..4449290 + 873 WP_000920762.1 virulence factor BrkB family protein -
EC958_RS22325 4449287..4449724 + 438 WP_000560981.1 D-tyrosyl-tRNA(Tyr) deacylase -
EC958_RS22330 4449769..4450710 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
EC958_RS22335 4450774..4451682 - 909 WP_001296611.1 alpha/beta hydrolase -
EC958_RS22340 4451911..4452222 + 312 WP_000897302.1 hypothetical protein Toxin
EC958_RS22345 4452223..4452513 + 291 WP_000356397.1 helix-turn-helix domain-containing protein Antitoxin
EC958_RS22355 4452872..4453150 + 279 WP_001296612.1 hypothetical protein -
EC958_RS22360 4453547..4453765 + 219 WP_001251293.1 ribbon-helix-helix domain-containing protein -
EC958_RS22365 4453950..4454399 - 450 WP_032140890.1 hypothetical protein -
EC958_RS22370 4454715..4455563 - 849 WP_001038650.1 hypothetical protein -
EC958_RS22375 4455853..4456095 + 243 WP_001068514.1 ribbon-helix-helix domain-containing protein -
EC958_RS22380 4456277..4457206 - 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T285207 WP_000897302.1 NZ_HG941718:4451911-4452222 [Escherichia coli O25b:H4-ST131]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT285207 WP_000356397.1 NZ_HG941718:4452223-4452513 [Escherichia coli O25b:H4-ST131]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References