285199

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2289134..2289636 Replicon chromosome
Accession NZ_HG941718
Organism Escherichia coli O25b:H4-ST131 strain EC958

Toxin (Protein)


Gene name yoeB Uniprot ID E2QNP2
Locus tag EC958_RS11895 Protein ID WP_000767819.1
Coordinates 2289134..2289388 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID E2QNP3
Locus tag EC958_RS11900 Protein ID WP_001259253.1
Coordinates 2289385..2289636 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC958_RS11870 2284952..2285410 - 459 WP_001531805.1 IS200/IS605-like element IS200C family transposase -
EC958_RS11880 2285627..2286985 - 1359 WP_000019194.1 putrescine/proton symporter PlaP -
EC958_RS29280 2286975..2287037 - 63 WP_010723108.1 membrane protein YoeI -
EC958_RS11885 2287252..2288181 - 930 WP_000803366.1 LysR family transcriptional regulator -
EC958_RS11890 2288227..2289051 - 825 WP_000754737.1 SDR family oxidoreductase -
EC958_RS11895 2289134..2289388 - 255 WP_000767819.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
EC958_RS11900 2289385..2289636 - 252 WP_001259253.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
EC958_RS27260 2289919..2289969 + 51 WP_001364200.1 his operon leader peptide -
EC958_RS11905 2290115..2291014 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
EC958_RS11910 2291020..2292324 + 1305 WP_001296211.1 histidinol dehydrogenase -
EC958_RS11915 2292321..2293391 + 1071 WP_000108967.1 histidinol-phosphate transaminase -
EC958_RS11920 2293391..2294458 + 1068 WP_000080057.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2284952..2285410 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10110.53 Da        Isoelectric Point: 7.2749

>T285199 WP_000767819.1 NZ_HG941718:c2289388-2289134 [Escherichia coli O25b:H4-ST131]
VKLIWSEESWDDYLYWQEADKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHLLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9365.62 Da        Isoelectric Point: 4.6127

>AT285199 WP_001259253.1 NZ_HG941718:c2289636-2289385 [Escherichia coli O25b:H4-ST131]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSDKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E2QNP2

Antitoxin

Source ID Structure
AlphaFold DB E2QNP3

References