Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1859237..1859750 Replicon chromosome
Accession NZ_HG939456
Organism Streptococcus agalactiae COH1

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DX49
Locus tag GBSCOH1_RS09260 Protein ID WP_000481712.1
Coordinates 1859237..1859491 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q8DX48
Locus tag GBSCOH1_RS09265 Protein ID WP_000387490.1
Coordinates 1859484..1859750 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GBSCOH1_RS09240 1855001..1857502 - 2502 WP_000239414.1 ATP-binding protein -
GBSCOH1_RS09245 1857523..1857933 - 411 WP_000390747.1 conjugal transfer protein -
GBSCOH1_RS09250 1857944..1858210 - 267 WP_001055037.1 hypothetical protein -
GBSCOH1_RS09255 1858231..1859184 - 954 WP_000565540.1 conjugal transfer protein -
GBSCOH1_RS09260 1859237..1859491 - 255 WP_000481712.1 Txe/YoeB family addiction module toxin Toxin
GBSCOH1_RS09265 1859484..1859750 - 267 WP_000387490.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
GBSCOH1_RS09270 1859895..1860368 - 474 WP_000560386.1 hypothetical protein -
GBSCOH1_RS09275 1860376..1860858 - 483 WP_000383283.1 antirestriction protein ArdA -
GBSCOH1_RS09280 1860911..1861183 - 273 WP_000017154.1 hypothetical protein -
GBSCOH1_RS09285 1861318..1861887 - 570 WP_000010056.1 hypothetical protein -
GBSCOH1_RS09290 1861890..1863239 - 1350 WP_000491712.1 AAA family ATPase -
GBSCOH1_RS09295 1863436..1863735 - 300 WP_000737133.1 helix-turn-helix domain-containing protein -
GBSCOH1_RS09300 1863719..1864096 - 378 WP_000287186.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - cfa/cfb / cfa/cfb / groEL 1848000..2014609 166609


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10445.87 Da        Isoelectric Point: 6.7282

>T285184 WP_000481712.1 NZ_HG939456:c1859491-1859237 [Streptococcus agalactiae COH1]
MFNFTEEAWKDYVSWQQEDKKILKRINRLIEDIKRDPFEGIGKPEPLKYHYSGAWSRRITEEHRLIYMIEDGEIYFLSFR
DHYK

Download         Length: 255 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10316.70 Da        Isoelectric Point: 4.6742

>AT285184 WP_000387490.1 NZ_HG939456:c1859750-1859484 [Streptococcus agalactiae COH1]
MEAIVYSHFRNNLKDYMKKVNDEFEPLIVVNKNPDENIVVLSQDSWESLQETIRLMENDYLSHKVINGISQVKEKQVTKH
GLIEVEDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829IC12

Antitoxin

Source ID Structure
AlphaFold DB A0A829I9V6

References