Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2725241..2725817 Replicon chromosome
Accession NZ_HG938355
Organism Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI 1141

Toxin (Protein)


Gene name higB Uniprot ID A0A068T9B4
Locus tag RG1141_RS13765 Protein ID WP_038544643.1
Coordinates 2725539..2725817 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag RG1141_RS13760 Protein ID WP_038588996.1
Coordinates 2725241..2725525 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG1141_RS13730 2720535..2720921 - 387 WP_038544630.1 hypothetical protein -
RG1141_RS13735 2720963..2721985 + 1023 WP_038544631.1 RluA family pseudouridine synthase -
RG1141_RS13740 2722056..2722889 + 834 WP_038544633.1 AraC family transcriptional regulator -
RG1141_RS32480 2722983..2723144 + 162 WP_173426754.1 hypothetical protein -
RG1141_RS13745 2723251..2723556 + 306 WP_038544635.1 DUF1127 domain-containing protein -
RG1141_RS13750 2723805..2724707 + 903 WP_038544637.1 RNA polymerase sigma factor RpoH -
RG1141_RS13755 2724800..2725183 + 384 WP_038544639.1 ACT domain-containing protein -
RG1141_RS13760 2725241..2725525 - 285 WP_038588996.1 HigA family addiction module antidote protein Antitoxin
RG1141_RS13765 2725539..2725817 - 279 WP_038544643.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
RG1141_RS13770 2725891..2728584 - 2694 WP_038544644.1 hypothetical protein -
RG1141_RS13775 2728644..2729942 - 1299 WP_038544646.1 adenylosuccinate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(8-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(7-64)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10256.55 Da        Isoelectric Point: 6.2136

>T285165 WP_038544643.1 NZ_HG938355:c2725817-2725539 [Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI]
MIKSWVNSSTRRFAEEGKSKFSGMDEEAAIELLAALHAASSLNDLSPLKSVGLHKLSGNRSGQWAMTINGPWRICFTFRD
GDAWDVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10414.97 Da        Isoelectric Point: 10.2943

>AT285165 WP_038588996.1 NZ_HG938355:c2725525-2725241 [Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI]
MIAVHPGRILKRELTARSLSANQLALSLRLPSGRITDILNAKRGISPDTALRLARYFGNSARFWLDLQTAYELALAEREN
GERIAEEVKPAEAA

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A068T9B4

Antitoxin

Source ID Structure

References