285147

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2823096..2823672 Replicon chromosome
Accession NZ_HG938353
Organism Neorhizobium galegae bv. orientalis str. HAMBI 540

Toxin (Protein)


Gene name higB Uniprot ID A0A068STC6
Locus tag RG540_RS14040 Protein ID WP_038588998.1
Coordinates 2823394..2823672 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag RG540_RS14035 Protein ID WP_038588996.1
Coordinates 2823096..2823380 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG540_RS14005 2818386..2818772 - 387 WP_038588983.1 hypothetical protein -
RG540_RS14010 2818826..2819848 + 1023 WP_038588985.1 RluA family pseudouridine synthase -
RG540_RS14015 2819919..2820752 + 834 WP_038588988.1 AraC family transcriptional regulator -
RG540_RS32855 2820845..2821006 + 162 WP_167551674.1 hypothetical protein -
RG540_RS14020 2821107..2821412 + 306 WP_038588991.1 DUF1127 domain-containing protein -
RG540_RS14025 2821662..2822564 + 903 WP_038588993.1 RNA polymerase sigma factor RpoH -
RG540_RS14030 2822655..2823038 + 384 Protein_2804 ACT domain-containing protein -
RG540_RS14035 2823096..2823380 - 285 WP_038588996.1 HigA family addiction module antidote protein Antitoxin
RG540_RS14040 2823394..2823672 - 279 WP_038588998.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
RG540_RS14045 2823742..2826450 - 2709 WP_038589002.1 hypothetical protein -
RG540_RS14050 2826510..2827808 - 1299 WP_038589004.1 adenylosuccinate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(8-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(7-64)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10341.66 Da        Isoelectric Point: 6.2136

>T285147 WP_038588998.1 NZ_HG938353:c2823672-2823394 [Neorhizobium galegae bv. orientalis str. HAMBI 540]
MIKSWVNSSTRRFAEEGKSKFSGMNEEASIELLAALHAASSLNDLSPLKSVGLHKLSGNRLGQWAMTINGPWRICFTFRD
GDDWDVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10414.97 Da        Isoelectric Point: 10.2943

>AT285147 WP_038588996.1 NZ_HG938353:c2823380-2823096 [Neorhizobium galegae bv. orientalis str. HAMBI 540]
MIAVHPGRILKRELTARSLSANQLALSLRLPSGRITDILNAKRGISPDTALRLARYFGNSARFWLDLQTAYELALAEREN
GERIAEEVKPAEAA

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A068STC6

Antitoxin

Source ID Structure

References