285111

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 3796655..3797322 Replicon chromosome
Accession NZ_HG813240
Organism Mycobacterium tuberculosis 49-02

Toxin (Protein)


Gene name vapC Uniprot ID O50411
Locus tag MT49_RS17850 Protein ID WP_003417916.1
Coordinates 3796655..3797047 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8U8S7
Locus tag MT49_RS17855 Protein ID WP_003912214.1
Coordinates 3797047..3797322 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT49_RS17825 3792502..3793491 - 990 WP_003417912.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
MT49_RS17830 3793491..3793880 - 390 Protein_3485 polyprenyl synthetase family protein -
MT49_RS17840 3793933..3795194 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
MT49_RS17845 3795236..3795901 - 666 Protein_3487 polyprenyl synthetase family protein -
MT49_RS17850 3796655..3797047 - 393 WP_003417916.1 type II toxin-antitoxin system VapC family toxin Toxin
MT49_RS17855 3797047..3797322 - 276 WP_003912214.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MT49_RS21835 3797534..3798875 + 1342 Protein_3490 ISNCY family transposase -
MT49_RS17870 3799065..3801242 + 2178 WP_016330440.1 PE family protein -
MT49_RS17875 3801313..3802185 - 873 WP_003906098.1 3-hydroxyacyl-thioester dehydratase HtdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside IScluster/Tn - - 3793933..3798875 4942


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14316.74 Da        Isoelectric Point: 10.7249

>T285111 WP_003417916.1 NZ_HG813240:c3797047-3796655 [Mycobacterium tuberculosis 49-02]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRHPRVSSALARAEVMRALLDKGESARKAGRRALAHLDLLRVDKRVLDLAG
GLLPFELRTLDAIHLATAQRLGVDLGRLCTYDDRMRDAAKTLGMAVIAPS

Download         Length: 393 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9966.35 Da        Isoelectric Point: 4.5332

>AT285111 WP_003912214.1 NZ_HG813240:c3797322-3797047 [Mycobacterium tuberculosis 49-02]
MTSVGVRALRQRASELLRRVEAGETIEITDRGRPVALLSPLPQGGPYEQLLASGEIERATLDVVDLPEPLDLDAGVELPS
VTLARLREHER

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BXS8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8U8S7

References