Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3544834..3545504 Replicon chromosome
Accession NZ_HG813240
Organism Mycobacterium tuberculosis 49-02

Toxin (Protein)


Gene name higB Uniprot ID O53332
Locus tag MT49_RS16770 Protein ID WP_003899954.1
Coordinates 3544834..3545178 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G0THF6
Locus tag MT49_RS16775 Protein ID WP_003899955.1
Coordinates 3545175..3545504 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT49_RS16740 3540139..3540432 + 294 WP_003416635.1 hypothetical protein -
MT49_RS16745 3540720..3542009 + 1290 WP_003416640.1 ATP-binding protein -
MT49_RS16760 3543714..3544148 - 435 WP_003899952.1 type II toxin-antitoxin system VapC family toxin -
MT49_RS16765 3544151..3544603 - 453 WP_003899953.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MT49_RS16770 3544834..3545178 + 345 WP_003899954.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MT49_RS16775 3545175..3545504 + 330 WP_003899955.1 XRE family transcriptional regulator Antitoxin
MT49_RS16780 3546042..3546389 + 348 WP_003899956.1 DUF2384 domain-containing protein -
MT49_RS16785 3546386..3547006 + 621 WP_003899957.1 RES family NAD+ phosphorylase -
MT49_RS16790 3547166..3548431 - 1266 WP_003902423.1 hypothetical protein -
MT49_RS16795 3548599..3548808 + 210 WP_003416778.1 hypothetical protein -
MT49_RS16805 3549055..3550089 - 1035 WP_003416786.1 IS30 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-91)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12692.50 Da        Isoelectric Point: 5.6920

>T285108 WP_003899954.1 NZ_HG813240:3544834-3545178 [Mycobacterium tuberculosis 49-02]
MAVILLPQVERWFFALNRDAMASVTGAIDLLEMEGPTLGRPVVDKVNDSTFHNMKELRPAGTSIRILFAFDPARQAILLL
GGDKAGNWKRWYDNNIPIADQRSENWLASEHGGG

Download         Length: 345 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11802.46 Da        Isoelectric Point: 7.4051

>AT285108 WP_003899955.1 NZ_HG813240:3545175-3545504 [Mycobacterium tuberculosis 49-02]
MTMARNWRDIRADAVAQGRVDLQRAAVAREEMRDAVLAHRLAEIRKALGHARQADVAALMGVSQARVSKLESGDLSHTEL
GTLQAYVAALGGHLRIVAEFGENTVELTA

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBK2

Antitoxin

Source ID Structure
PDB 6LTY
PDB 6LTZ
AlphaFold DB G0THF6

References