Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2258958..2259877 Replicon chromosome
Accession NZ_HG813240
Organism Mycobacterium tuberculosis 49-02

Toxin (Protein)


Gene name HigB2 Uniprot ID L7N4R2
Locus tag MT49_RS21360 Protein ID WP_003900449.1
Coordinates 2259272..2259877 (-) Length 202 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID L7N5K9
Locus tag MT49_RS10590 Protein ID WP_003410124.1
Coordinates 2258958..2259263 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT49_RS10550 2254221..2254421 + 201 Protein_2068 hypothetical protein -
MT49_RS10565 2255777..2256154 + 378 Protein_2070 hypothetical protein -
MT49_RS10570 2256151..2257191 + 1041 WP_003410103.1 ImmA/IrrE family metallo-endopeptidase -
MT49_RS10575 2257433..2258152 + 720 WP_003410108.1 DUF433 domain-containing protein -
MT49_RS10580 2258142..2258558 + 417 WP_003410114.1 hypothetical protein -
MT49_RS10585 2258574..2258873 - 300 WP_003410120.1 hypothetical protein -
MT49_RS10590 2258958..2259263 - 306 WP_003410124.1 XRE family transcriptional regulator Antitoxin
MT49_RS21360 2259272..2259877 - 606 WP_003900449.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MT49_RS10600 2259902..2260261 - 360 WP_003410131.1 hypothetical protein -
MT49_RS10605 2260421..2261098 - 678 WP_003905725.1 hypothetical protein -
MT49_RS10610 2261050..2261286 - 237 WP_003410133.1 hypothetical protein -
MT49_RS10615 2261493..2262389 - 897 WP_003410136.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(86-181)

Antitoxin

HigA2-like, helix-turn-helix domain

(32-92)


Sequences

Toxin        


Download         Length: 202 a.a.        Molecular weight: 22744.96 Da        Isoelectric Point: 7.3073

>T285090 WP_003900449.1 NZ_HG813240:c2259877-2259272 [Mycobacterium tuberculosis 49-02]
VNVPWENAHGGALYCLIRGDEFSAWHRLLFQRPGCAESVLACRHFLDGSPVARCSYPEEYHPCVISRIALLCDSVGWTAD
VERISAWLNGLDRETYELVFAAIEVLEEEGPALGCPLVDTVRGSRHKNMKELRPGSQGRSEVRILFAFDPARQAIMLAAG
NKAGRWTQWYDEKIKAADEMFAEHLAQFEDTKPKRRKRKKG

Download         Length: 606 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11291.91 Da        Isoelectric Point: 10.7482

>AT285090 WP_003410124.1 NZ_HG813240:c2259263-2258958 [Mycobacterium tuberculosis 49-02]
MAMTLRDMDAVRPVNREAVDRHKARMRDEVRAFRLRELRAAQSLTQVQVAALAHIRQSRVSSIENGDIGSAQVNTLRKYV
SALGGELDITVRLGDETFTLA

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BV20

Antitoxin

Source ID Structure
PDB 7EWC
PDB 7EWD
PDB 7EWE
AlphaFold DB A0A7U4BV30

References