Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4556972..4557702 Replicon chromosome
Accession NZ_HG738868
Organism Serratia marcescens SMB2099

Toxin (Protein)


Gene name higB Uniprot ID A0A2S4X738
Locus tag SMB2099_RS21595 Protein ID WP_033636137.1
Coordinates 4556972..4557283 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2V4GBG9
Locus tag SMB2099_RS21600 Protein ID WP_033636138.1
Coordinates 4557280..4557702 (+) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMB2099_RS21565 4552283..4553008 + 726 WP_004937040.1 LPS export ABC transporter ATP-binding protein -
SMB2099_RS21570 4553061..4554494 + 1434 WP_043141961.1 RNA polymerase factor sigma-54 -
SMB2099_RS21575 4554518..4554805 + 288 WP_004937038.1 ribosome hibernation promoting factor -
SMB2099_RS21580 4554961..4555422 + 462 WP_016930212.1 PTS IIA-like nitrogen regulatory protein PtsN -
SMB2099_RS21585 4555552..4556406 + 855 WP_015379177.1 RNase adapter RapZ -
SMB2099_RS21590 4556403..4556675 + 273 WP_033648996.1 PTS phosphocarrier protein NPr -
SMB2099_RS21595 4556972..4557283 + 312 WP_033636137.1 type II toxin-antitoxin system HigB family toxin Toxin
SMB2099_RS21600 4557280..4557702 + 423 WP_033636138.1 helix-turn-helix domain-containing protein Antitoxin
SMB2099_RS21605 4557707..4559623 - 1917 WP_079656867.1 BglG family transcription antiterminator -
SMB2099_RS21610 4559675..4560889 - 1215 WP_047570420.1 lactonase family protein -
SMB2099_RS21615 4560984..4561724 - 741 WP_004937022.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(81-135)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12259.11 Da        Isoelectric Point: 10.0957

>T285052 WP_033636137.1 NZ_HG738868:4556972-4557283 [Serratia marcescens SMB2099]
MHIISREPFNNATKQYPNEAAALEAIYKALRRGEFRTPDELKALFPSLDRMKYKEKWWVIDVGGNHLRILFFASFETQKV
FIKHIVSHAEYDKLMQHYRRSSS

Download         Length: 312 bp

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15676.97 Da        Isoelectric Point: 4.9590

>AT285052 WP_033636138.1 NZ_HG738868:4557280-4557702 [Serratia marcescens SMB2099]
MITDAIKAADALLRAVPLLQGSSSQQDYREALELVEYLLENDEHHPLIDMLAKKIAEYEDNSAEFTAFNQRIAQLPQGVA
ALRVLMEQHQLSQSDFEHEIGKKSLVSQILSGKRSLTIPHIMALAKRFNLPPALFLPEAD

Download         Length: 423 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S4X738

Antitoxin

Source ID Structure
AlphaFold DB A0A2V4GBG9

References