Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4094859..4095511 Replicon chromosome
Accession NZ_HG738868
Organism Serratia marcescens SMB2099

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag SMB2099_RS19350 Protein ID WP_041036518.1
Coordinates 4094859..4095203 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A086GAN0
Locus tag SMB2099_RS19355 Protein ID WP_004931828.1
Coordinates 4095209..4095511 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMB2099_RS19335 4091202..4093460 - 2259 WP_079656746.1 molybdopterin guanine dinucleotide-containing S/N-oxide reductase -
SMB2099_RS19345 4093681..4094700 + 1020 WP_033649496.1 HTH-type transcriptional regulator GalR -
SMB2099_RS19350 4094859..4095203 + 345 WP_041036518.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SMB2099_RS19355 4095209..4095511 + 303 WP_004931828.1 helix-turn-helix transcriptional regulator Antitoxin
SMB2099_RS19360 4095539..4096801 - 1263 WP_049232248.1 diaminopimelate decarboxylase -
SMB2099_RS19365 4096935..4097858 + 924 WP_033649494.1 LysR family transcriptional regulator -
SMB2099_RS19370 4097886..4098794 - 909 WP_015378928.1 LysR family transcriptional regulator -
SMB2099_RS19375 4098903..4099787 + 885 WP_041036524.1 MBL fold metallo-hydrolase -
SMB2099_RS19380 4099856..4100503 + 648 WP_033649493.1 DsbA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-85)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13425.48 Da        Isoelectric Point: 10.4277

>T285050 WP_041036518.1 NZ_HG738868:4094859-4095203 [Serratia marcescens SMB2099]
MWQVVTVERFDDWFLALNNAQQTSILAAIYKLQTFGPQLTRPHADTLYFSDAVRQLKELRVQHRGRPFRVFFAFDPQRQA
VLLCGGDKTGDKRFYQRMLPIAAMEFSHYLATRR

Download         Length: 345 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11080.97 Da        Isoelectric Point: 10.1998

>AT285050 WP_004931828.1 NZ_HG738868:4095209-4095511 [Serratia marcescens SMB2099]
MAKPLSQLIDKLDPAVVAAARQKADQEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A086GAN0

References