Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3343495..3344155 Replicon chromosome
Accession NZ_HG738868
Organism Serratia marcescens SMB2099

Toxin (Protein)


Gene name higB Uniprot ID A0A2V4GMA7
Locus tag SMB2099_RS15895 Protein ID WP_033647956.1
Coordinates 3343802..3344155 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2V4GQ69
Locus tag SMB2099_RS15890 Protein ID WP_033635213.1
Coordinates 3343495..3343797 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMB2099_RS15870 3339114..3340028 - 915 WP_004928592.1 branched-chain amino acid ABC transporter permease -
SMB2099_RS15875 3340154..3341272 - 1119 WP_033647954.1 branched-chain amino acid ABC transporter substrate-binding protein -
SMB2099_RS15885 3341878..3343086 - 1209 WP_041035902.1 aldose 1-epimerase family protein -
SMB2099_RS15890 3343495..3343797 - 303 WP_033635213.1 XRE family transcriptional regulator Antitoxin
SMB2099_RS15895 3343802..3344155 - 354 WP_033647956.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SMB2099_RS15900 3344596..3345891 + 1296 WP_048321788.1 MFS transporter -
SMB2099_RS15905 3345919..3346725 + 807 WP_079656629.1 substrate-binding domain-containing protein -
SMB2099_RS15910 3346700..3347599 - 900 WP_079656630.1 LysR family transcriptional regulator -
SMB2099_RS15915 3347692..3348057 - 366 WP_033635218.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13460.30 Da        Isoelectric Point: 8.9000

>T285048 WP_033647956.1 NZ_HG738868:c3344155-3343802 [Serratia marcescens SMB2099]
VWEIKTTDAFDNWFSSLHDADRAGVLAALMILREKGPGLPRPYADTVKGSRYSNMKELRIQSRGEPLRAFFAFDPYRIGI
VLCAGNKAGNEKRFYDRMIQAADREFTNWLNTLNEKE

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11079.94 Da        Isoelectric Point: 6.4738

>AT285048 WP_033635213.1 NZ_HG738868:c3343797-3343495 [Serratia marcescens SMB2099]
MGRTLEQLIADEKPEVVAKAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V4GMA7

Antitoxin

Source ID Structure
AlphaFold DB A0A2V4GQ69

References