Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 616664..617317 Replicon chromosome
Accession NZ_HG738868
Organism Serratia marcescens SMB2099

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag SMB2099_RS02870 Protein ID WP_033645671.1
Coordinates 616664..617014 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A5C7DBM3
Locus tag SMB2099_RS02875 Protein ID WP_019453270.1
Coordinates 617018..617317 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMB2099_RS02840 612215..612625 - 411 WP_033648574.1 GNAT family N-acetyltransferase -
SMB2099_RS02845 612654..614024 - 1371 WP_039567579.1 glutamine synthetase family protein -
SMB2099_RS02850 614270..614569 + 300 WP_077791580.1 hypothetical protein -
SMB2099_RS02860 614994..615389 - 396 WP_079656958.1 hypothetical protein -
SMB2099_RS02865 615389..616392 - 1004 Protein_538 hypothetical protein -
SMB2099_RS02870 616664..617014 + 351 WP_033645671.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SMB2099_RS02875 617018..617317 + 300 WP_019453270.1 XRE family transcriptional regulator Antitoxin
SMB2099_RS02880 617307..618224 - 918 WP_033648568.1 LysR family transcriptional regulator -
SMB2099_RS02885 618393..619091 + 699 WP_033648567.1 CoA transferase subunit A -
SMB2099_RS02890 619103..619756 + 654 WP_033648566.1 CoA transferase subunit B -
SMB2099_RS02895 619770..620954 + 1185 WP_033648565.1 acetyl-CoA C-acetyltransferase -
SMB2099_RS02900 620973..621896 + 924 WP_033648563.1 3-hydroxyacyl-CoA dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13546.81 Da        Isoelectric Point: 8.2699

>T285041 WP_033645671.1 NZ_HG738868:616664-617014 [Serratia marcescens SMB2099]
MWTVMTTEEFDRWLCEQDESTQEKVLAALVMLERAGPSLRRPFVDVLKGSLHPNMKELRIQHKGRPIRAFFAFDPARQAI
VLCAGDKTGNEKRFYKVMLPIADAQFTQYLMCYFKE

Download         Length: 351 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11013.71 Da        Isoelectric Point: 7.3207

>AT285041 WP_019453270.1 NZ_HG738868:617018-617317 [Serratia marcescens SMB2099]
MSTLKQLLASRTPESRRRIEEMAEEMLFEAHLHQLREALNISQQELAKTLGISQPSVAAIEGRGNELKISTLKRYVEAMG
GTLRLDVELPGGKHVGFTV

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5C7DBM3

References