Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2652119..2652779 Replicon chromosome
Accession NZ_HG326223
Organism Serratia marcescens subsp. marcescens Db11

Toxin (Protein)


Gene name higB Uniprot ID A0A656VMD8
Locus tag SMDB11_RS12350 Protein ID WP_025303493.1
Coordinates 2652426..2652779 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8G2G5Z5
Locus tag SMDB11_RS12345 Protein ID WP_016927038.1
Coordinates 2652119..2652421 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMDB11_RS12325 2647723..2648637 - 915 WP_004928592.1 branched-chain amino acid ABC transporter permease -
SMDB11_RS12330 2648763..2649881 - 1119 WP_016927040.1 branched-chain amino acid ABC transporter substrate-binding protein -
SMDB11_RS12340 2650487..2651695 - 1209 WP_025303492.1 aldose 1-epimerase family protein -
SMDB11_RS12345 2652119..2652421 - 303 WP_016927038.1 XRE family transcriptional regulator Antitoxin
SMDB11_RS12350 2652426..2652779 - 354 WP_025303493.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SMDB11_RS12355 2653218..2654513 + 1296 WP_025303494.1 MFS transporter -
SMDB11_RS12360 2654540..2655346 + 807 WP_025303495.1 substrate-binding domain-containing protein -
SMDB11_RS12365 2655321..2656220 - 900 WP_025303496.1 LysR family transcriptional regulator -
SMDB11_RS12370 2656324..2656689 - 366 WP_025303497.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13548.47 Da        Isoelectric Point: 9.0170

>T284995 WP_025303493.1 NZ_HG326223:c2652779-2652426 [Serratia marcescens subsp. marcescens Db11]
VWEIKTTDAFDHWYRSLSDADRAGVLAALMVLREKGPGLPRPYADTVKGSRYSNMKELRIQCRGEPLRAFFAFDPYRIGI
VLCAGNKAGNEKRFYDRMIQVADREFTNWLNTLNEKE

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11093.96 Da        Isoelectric Point: 6.4738

>AT284995 WP_016927038.1 NZ_HG326223:c2652421-2652119 [Serratia marcescens subsp. marcescens Db11]
MGRTLEQLIADEKPEVVAKAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDIELPDGSHYEFVL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656VMD8

Antitoxin

Source ID Structure

References