Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4656258..4656860 Replicon chromosome
Accession NZ_HF572917
Organism Escherichia coli strain HUSEC2011

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag HUS2011_RS24355 Protein ID WP_000897305.1
Coordinates 4656258..4656569 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HUS2011_RS24360 Protein ID WP_000356397.1
Coordinates 4656570..4656860 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUS2011_RS24330 4652172..4652771 + 600 WP_001295269.1 glucose-1-phosphatase -
HUS2011_RS24335 4652765..4653637 + 873 WP_000920762.1 virulence factor BrkB family protein -
HUS2011_RS24340 4653634..4654071 + 438 WP_000560983.1 D-tyrosyl-tRNA(Tyr) deacylase -
HUS2011_RS24345 4654116..4655057 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
HUS2011_RS24350 4655121..4656029 - 909 WP_001387201.1 alpha/beta hydrolase -
HUS2011_RS24355 4656258..4656569 + 312 WP_000897305.1 hypothetical protein Toxin
HUS2011_RS24360 4656570..4656860 + 291 WP_000356397.1 helix-turn-helix domain-containing protein Antitoxin
HUS2011_RS24365 4657446..4657664 + 219 WP_001315930.1 ribbon-helix-helix domain-containing protein -
HUS2011_RS24370 4657884..4658126 + 243 WP_001087409.1 hypothetical protein -
HUS2011_RS24380 4658456..4659385 - 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
HUS2011_RS24385 4659382..4660017 - 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
HUS2011_RS24390 4660014..4660916 - 903 WP_000331377.1 formate dehydrogenase O subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T284971 WP_000897305.1 NZ_HF572917:4656258-4656569 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT284971 WP_000356397.1 NZ_HF572917:4656570-4656860 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References