Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3781623..3782422 Replicon chromosome
Accession NZ_HF572917
Organism Escherichia coli strain HUSEC2011

Toxin (Protein)


Gene name yhaV Uniprot ID U9XVR9
Locus tag HUS2011_RS19970 Protein ID WP_000347267.1
Coordinates 3781958..3782422 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag HUS2011_RS19965 Protein ID WP_001307405.1
Coordinates 3781623..3781958 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUS2011_RS19950 3777409..3778179 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
HUS2011_RS19955 3778195..3779529 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
HUS2011_RS19960 3779903..3781474 + 1572 WP_001273741.1 galactarate dehydratase -
HUS2011_RS19965 3781623..3781958 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
HUS2011_RS19970 3781958..3782422 + 465 WP_000347267.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
HUS2011_RS19975 3782477..3783286 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
HUS2011_RS19980 3783535..3784815 + 1281 WP_000681935.1 tagatose-bisphosphate aldolase subunit KbaZ -
HUS2011_RS19985 3784838..3785311 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
HUS2011_RS19990 3785322..3786101 + 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
HUS2011_RS19995 3786091..3786969 + 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
HUS2011_RS20000 3786987..3787421 + 435 WP_000948824.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3769357..3782422 13065


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17807.17 Da        Isoelectric Point: 9.4947

>T284969 WP_000347267.1 NZ_HF572917:3781958-3782422 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT284969 WP_001307405.1 NZ_HF572917:3781623-3781958 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XTR4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References