Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2485225..2485727 Replicon chromosome
Accession NZ_HF572917
Organism Escherichia coli strain HUSEC2011

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag HUS2011_RS13730 Protein ID WP_000767829.1
Coordinates 2485225..2485479 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag HUS2011_RS13735 Protein ID WP_001259255.1
Coordinates 2485476..2485727 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUS2011_RS13705 2480240..2480467 - 228 WP_000985273.1 sulfurtransferase TusA family protein -
HUS2011_RS13710 2480481..2481539 - 1059 WP_000492324.1 transport protein YeeE -
HUS2011_RS13715 2481718..2483076 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
HUS2011_RS31365 2483066..2483128 - 63 WP_010723108.1 membrane protein YoeI -
HUS2011_RS13720 2483343..2484272 - 930 WP_000803366.1 LysR family transcriptional regulator -
HUS2011_RS13725 2484318..2485142 - 825 WP_000754758.1 SDR family oxidoreductase -
HUS2011_RS13730 2485225..2485479 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
HUS2011_RS13735 2485476..2485727 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
HUS2011_RS29845 2486011..2486061 + 51 WP_001364200.1 his operon leader peptide -
HUS2011_RS13740 2486207..2487106 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
HUS2011_RS13745 2487112..2488416 + 1305 WP_001386882.1 histidinol dehydrogenase -
HUS2011_RS13750 2488413..2489483 + 1071 WP_000108967.1 histidinol-phosphate transaminase -
HUS2011_RS13755 2489483..2490550 + 1068 WP_000080087.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T284964 WP_000767829.1 NZ_HF572917:c2485479-2485225 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT284964 WP_001259255.1 NZ_HF572917:c2485727-2485476 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References