Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 277330..277871 Replicon chromosome
Accession NZ_HF572917
Organism Escherichia coli strain HUSEC2011

Toxin (Protein)


Gene name yafQ Uniprot ID B7LHF6
Locus tag HUS2011_RS02255 Protein ID WP_000615974.1
Coordinates 277330..277608 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag HUS2011_RS02260 Protein ID WP_000729704.1
Coordinates 277611..277871 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUS2011_RS02240 274912..275490 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
HUS2011_RS02245 275696..276463 + 768 WP_000333380.1 class II glutamine amidotransferase -
HUS2011_RS02250 276434..277174 - 741 WP_001225679.1 murein L,D-transpeptidase -
HUS2011_RS02255 277330..277608 - 279 WP_000615974.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
HUS2011_RS02260 277611..277871 - 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
HUS2011_RS02265 278057..278830 + 774 WP_000543895.1 C40 family peptidase -
HUS2011_RS02270 278887..279243 - 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
HUS2011_RS02275 279236..279514 - 279 WP_000598758.1 type II toxin-antitoxin system HicA family toxin -
HUS2011_RS02280 279619..281331 - 1713 Protein_245 flagellar biosynthesis protein FlhA -
HUS2011_RS02285 281303..282088 + 786 WP_000207574.1 putative lateral flagellar export/assembly protein LafU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10855.68 Da        Isoelectric Point: 10.2267

>T284955 WP_000615974.1 NZ_HF572917:c277608-277330 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMRLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT284955 WP_000729704.1 NZ_HF572917:c277871-277611 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y514

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References