Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 114378..115052 Replicon plasmid megaplasmid
Accession NZ_FO818638
Organism Xenorhabdus bovienii strain CS03

Toxin (Protein)


Gene name higB Uniprot ID A0A0B6XEM2
Locus tag XBW1_RS21965 Protein ID WP_046338236.1
Coordinates 114378..114701 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag XBW1_RS21970 Protein ID WP_046338237.1
Coordinates 114756..115052 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XBW1_RS21945 109617..111197 - 1581 WP_046338233.1 hypothetical protein -
XBW1_RS21950 111243..113033 - 1791 WP_065814070.1 capsid protein -
XBW1_RS21955 113213..113629 + 417 WP_046338234.1 hypothetical protein -
XBW1_RS21960 113670..114047 + 378 WP_046338235.1 DUF2591 family protein -
XBW1_RS21965 114378..114701 + 324 WP_046338236.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
XBW1_RS21970 114756..115052 + 297 WP_046338237.1 helix-turn-helix domain-containing protein Antitoxin
XBW1_RS23675 115054..115170 + 117 WP_155399224.1 toxin-antitoxin system HicB family antitoxin -
XBW1_RS22675 115461..115913 - 453 WP_052726145.1 hypothetical protein -
XBW1_RS21980 115922..116662 - 741 WP_046338239.1 hypothetical protein -
XBW1_RS21985 116959..117795 - 837 WP_046338240.1 Dam family site-specific DNA-(adenine-N6)-methyltransferase -
XBW1_RS21990 117788..118720 - 933 WP_052726146.1 recombination-associated protein RdgC -
XBW1_RS22815 118935..119180 + 246 WP_046338241.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
XBW1_RS22000 119180..119530 + 351 WP_046338292.1 type II toxin-antitoxin system PemK/MazF family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..177250 177250


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(10-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-82)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12582.48 Da        Isoelectric Point: 9.6096

>T284919 WP_046338236.1 NZ_FO818638:114378-114701 [Xenorhabdus bovienii]
MDYLEFIETTTFSRVRTELMEDDELQELQDHLLKHHEKGDTISQTGGCKKIRWSRKGMGKRGGIRVIYYVRTLSGRLYLL
LVYPKNAQADLTQDQKTQLKNAIQYMK

Download         Length: 324 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11117.92 Da        Isoelectric Point: 7.4044

>AT284919 WP_046338237.1 NZ_FO818638:114756-115052 [Xenorhabdus bovienii]
MDDKLFDDLLSSVKEMVAIENGEFQPKPEHVHRHAIPSVKSIRNHFGMKQVEFAEMIGVSVALVQSWESKRRTPSGTALK
MLFLIEKNPNIVDTLKSI

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B6XEM2

Antitoxin

Source ID Structure

References