Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4328..4974 Replicon plasmid megaplasmid
Accession NZ_FO818638
Organism Xenorhabdus bovienii strain CS03

Toxin (Protein)


Gene name higB Uniprot ID A0A077NLI8
Locus tag XBW1_RS21405 Protein ID WP_038197339.1
Coordinates 4624..4974 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A077NWX3
Locus tag XBW1_RS21400 Protein ID WP_038197338.1
Coordinates 4328..4627 (-) Length 100 a.a.

Genomic Context

XBW1_RS21375XBW1_RS24965XBW1_RS21385XBW1_RS23640XBW1_RS21390XBW1_RS21395XBW1_RS21415XBW1_RS21420XBW1_RS21425XBW1_RS21400XBW1_RS21405XBW1_RS21410XBW1_RS25235XBW1_RS23645XBW1_RS21430XBW1_RS21435
Location: 154..1161 (1008 bp)
Type: Others
Protein ID: WP_046338156.1
Location: 1574..1743 (170 bp)
Type: Others
Protein ID: Protein_1
Location: 1808..2498 (691 bp)
Type: Others
Protein ID: Protein_2
Location: 2538..2681 (144 bp)
Type: Others
Protein ID: WP_082243393.1
Location: 2906..3247 (342 bp)
Type: Others
Protein ID: WP_038195432.1
Location: 3487..4180 (694 bp)
Type: Others
Protein ID: WP_155399208.1
Location: 6003..6335 (333 bp)
Type: Others
Protein ID: WP_038196315.1
Location: 6325..6660 (336 bp)
Type: Others
Protein ID: WP_046338158.1
Location: 6986..7660 (675 bp)
Type: Others
Protein ID: WP_172664735.1
Location: 4328..4627 (300 bp)
Type: Antitoxin
Protein ID: WP_038197338.1
Location: 4624..4974 (351 bp)
Type: Toxin
Protein ID: WP_038197339.1
Location: 5144..5834 (691 bp)
Type: Others
Protein ID: Protein_8
Location: 6758..6889 (132 bp)
Type: Others
Protein ID: Protein_11
Location: 7668..7739 (72 bp)
Type: Others
Protein ID: WP_071839248.1
Location: 7963..8181 (219 bp)
Type: Others
Protein ID: WP_046338161.1
Location: 8493..9452 (960 bp)
Type: Others
Protein ID: WP_046338162.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
XBW1_RS21375154..1161+1008WP_046338156.1RepB family plasmid replication initiator protein-
XBW1_RS249651574..1743+170Protein_1IS6 family transposase-
XBW1_RS213851808..2498+691Protein_2IS6 family transposase-
XBW1_RS236402538..2681+144WP_082243393.1type II toxin-antitoxin system RelE/ParE family toxin-
XBW1_RS213902906..3247+342WP_038195432.1VOC family protein-
XBW1_RS213953487..4180+694WP_155399208.1IS6 family transposase-
XBW1_RS214004328..4627-300WP_038197338.1XRE family transcriptional regulatorAntitoxin
XBW1_RS214054624..4974-351WP_038197339.1type II toxin-antitoxin system RelE/ParE family toxinToxin
XBW1_RS214105144..5834-691Protein_8IS6 family transposase-
XBW1_RS214156003..6335+333WP_038196315.1type II toxin-antitoxin system Phd/YefM family antitoxin-
XBW1_RS214206325..6660+336WP_046338158.1hypothetical protein-
XBW1_RS252356758..6889-132Protein_11IS6 family transposase-
XBW1_RS214256986..7660+675WP_172664735.1transposase-
XBW1_RS236457668..7739-72WP_071839248.1transposase-
XBW1_RS214307963..8181-219WP_046338161.1hypothetical protein-
XBW1_RS214358493..9452-960WP_046338162.1SDR family NAD(P)-dependent oxidoreductase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..177250177250
-insideIScluster/Tn--1574..58344260


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13570.46 Da        Isoelectric Point: 7.2767

>T284917 WP_038197339.1 NZ_FO818638:c4974-4624 [Xenorhabdus bovienii]
MWTVIFTPRFDAWLQEQEEGMQEKVLADLTNLETYGPKLSRPYADTVKGSRHKNMKELRVQYSGHPVRAFFAFDPKRQAI
VLCAGDKSNNKRFYDTMIRIADEEFTAHLTVIEEQK

Download         Length: 351 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10974.70 Da        Isoelectric Point: 5.8787

>AT284917 WP_038197338.1 NZ_FO818638:c4627-4328 [Xenorhabdus bovienii]
MKTLRDAVAARSPESQARIKEMADEMILETGLQLMREELQFSQKSLAESMGVSQPAITQIEQRGNDVKLATLKRYIEAMG
GKLSLTVELPEGGGRIFHI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A077NLI8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A077NWX3

References