Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1751830..1752434 Replicon chromosome
Accession NZ_FO818637
Organism Xenorhabdus bovienii strain CS03

Toxin (Protein)


Gene name higB Uniprot ID A0A077NT86
Locus tag XBW1_RS08290 Protein ID WP_038223617.1
Coordinates 1751830..1752141 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag XBW1_RS08295 Protein ID WP_038182073.1
Coordinates 1752144..1752434 (+) Length 97 a.a.

Genomic Context

XBW1_RS08270XBW1_RS08285XBW1_RS08290XBW1_RS08295XBW1_RS08300XBW1_RS24545XBW1_RS24550XBW1_RS24555XBW1_RS08320XBW1_RS24560XBW1_RS08325XBW1_RS08335XBW1_RS08260XBW1_RS23130XBW1_RS08275XBW1_RS08280XBW1_RS23925XBW1_RS22735
Location: 1749381..1750022 (642 bp)
Type: Others
Protein ID: WP_082243316.1
Location: 1750832..1751278 (447 bp)
Type: Others
Protein ID: Protein_1653
Location: 1751830..1752141 (312 bp)
Type: Toxin
Protein ID: WP_038223617.1
Location: 1752144..1752434 (291 bp)
Type: Antitoxin
Protein ID: WP_038182073.1
Location: 1752619..1752924 (306 bp)
Type: Others
Protein ID: WP_155271852.1
Location: 1753761..1753940 (180 bp)
Type: Others
Protein ID: WP_155271853.1
Location: 1754040..1754381 (342 bp)
Type: Others
Protein ID: Protein_1660
Location: 1754484..1754798 (315 bp)
Type: Others
Protein ID: WP_155399196.1
Location: 1755047..1755760 (714 bp)
Type: Others
Protein ID: WP_082243317.1
Location: 1755959..1756132 (174 bp)
Type: Others
Protein ID: WP_155270976.1
Location: 1756129..1756542 (414 bp)
Type: Others
Protein ID: WP_052726022.1
Location: 1756988..1757194 (207 bp)
Type: Others
Protein ID: WP_038223228.1
Location: 1747771..1748949 (1179 bp)
Type: Others
Protein ID: WP_046336590.1
Location: 1749968..1750183 (216 bp)
Type: Others
Protein ID: WP_071839192.1
Location: 1750193..1750486 (294 bp)
Type: Others
Protein ID: WP_046336591.1
Location: 1750471..1750677 (207 bp)
Type: Others
Protein ID: WP_046336592.1
Location: 1752966..1753241 (276 bp)
Type: Others
Protein ID: WP_046336593.1
Location: 1753384..1753689 (306 bp)
Type: Others
Protein ID: WP_038223619.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
XBW1_RS082601747771..1748949-1179WP_046336590.1tyrosine-type recombinase/integrase-
XBW1_RS082701749381..1750022+642WP_082243316.1Arm DNA-binding domain-containing protein-
XBW1_RS231301749968..1750183-216WP_071839192.1hypothetical protein-
XBW1_RS082751750193..1750486-294WP_046336591.1hypothetical protein-
XBW1_RS082801750471..1750677-207WP_046336592.1hypothetical protein-
XBW1_RS082851750832..1751278+447Protein_1653winged helix-turn-helix domain-containing protein-
XBW1_RS082901751830..1752141+312WP_038223617.1toxin HigB-2Toxin
XBW1_RS082951752144..1752434+291WP_038182073.1helix-turn-helix domain-containing proteinAntitoxin
XBW1_RS083001752619..1752924+306WP_155271852.1hypothetical protein-
XBW1_RS239251752966..1753241-276WP_046336593.1DUF4236 domain-containing protein-
XBW1_RS227351753384..1753689-306WP_038223619.1Arc family DNA-binding protein-
XBW1_RS245451753761..1753940+180WP_155271853.1hypothetical protein-
XBW1_RS245501754040..1754381+342Protein_1660KilA-N domain-containing protein-
XBW1_RS245551754484..1754798+315WP_155399196.1phage antirepressor KilAC domain-containing protein-
XBW1_RS083201755047..1755760+714WP_082243317.1phage antirepressor N-terminal domain-containing protein-
XBW1_RS245601755959..1756132+174WP_155270976.1hypothetical protein-
XBW1_RS083251756129..1756542+414WP_052726022.1type II toxin-antitoxin system death-on-curing family toxin-
XBW1_RS083351756988..1757194+207WP_038223228.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--1743472..178560142129


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(42-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-74)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11993.73 Da        Isoelectric Point: 8.8435

>T284912 WP_038223617.1 NZ_FO818637:1751830-1752141 [Xenorhabdus bovienii]
MIFIETHIFTEDCKELLSDDEYREFQQYLADNPATGDVIQHTGGLRKVRWASRGKGKRGGVRVIYYHKVDVSHIRLLLIY
KKGIKDDLSESEKKVLRALNEGW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10627.32 Da        Isoelectric Point: 10.7721

>AT284912 WP_038182073.1 NZ_FO818637:1752144-1752434 [Xenorhabdus bovienii]
MDSKLFSRLTESMTQMNEIMNGERAASRETTIEAVKVKNIRQATGLSQTGFAKLISVNVGTLRNWEQGRREPTGPAKALL
KAIEKDPVHVLKALSM

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A077NT86

Antitoxin

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Source
ID
Structure
No matching records found

References